Study of relation on breast cancer and rs3803662 polymorphism of TOX3 gene in Iranian female population by Tetra Arms PCR

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SIASI ELHAM; Ghane Bahareh; ASHRAFI FATEMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:3 Page(s): 61-74

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Title

Study of relation on breast cancer and rs3803662 polymorphism of TOX3 gene in Iranian female population by Tetra Arms PCR

Author(s)

SIASI ELHAM | Ghane Bahareh | ASHRAFI FATEMEH | Issue Writer Certificate

Keywords

Breast CancerQ1

rs3803662 PolymorphismQ1

TOX3 GeneQ1

Tetra Arms PCRQ1

Abstract

TOX3 Gene plays an important role in the risk of Breast Cancer in females. Polymorphisms were identified in this gene, that can associated with Breast Cancer. The aim of this study was relation between Breast Cancer and rs3803662 Polymorphism of TOX3 Gene in Iranian females by Tetra Arms PCR. Blood samples were collected from 50 normal groups and 50 Breast Cancer Patients. Then was extracted DNA from samples. Genotype frequency of this polymorphism in TOX3 Gene were determined by using Tetra Arms PCR. Genotyp frequency for TT, TC and CC in normal groups was 10%, 88% and 2%, and For patient groups was 6%, 50% and 44%, respectively. Frequency of CC recessive homozygous genotype of rs3803662 Polymorphism in TOX3 Gene between normal groups and Breast Cancer patients was statistical significant difference (P < 0. 05). This research for first time was studied relation between the risk of Breast Cancer and presence of rs3803662 Polymorphism in TOX3 Gene in Iranian females. The results of this study was showed that presence of rs3803662 Polymorphism in TOX3 Gene, as genetic marker, can associated with Breast Cancer in Iranian female.

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APA: Copy

SIASI, ELHAM, Ghane, Bahareh, & ASHRAFI, FATEMEH. (2019). Study of relation on breast cancer and rs3803662 polymorphism of TOX3 gene in Iranian female population by Tetra Arms PCR. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(3 ), 61-74. SID. https://sid.ir/paper/193104/en

Vancouver: Copy

SIASI ELHAM, Ghane Bahareh, ASHRAFI FATEMEH. Study of relation on breast cancer and rs3803662 polymorphism of TOX3 gene in Iranian female population by Tetra Arms PCR. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(3 ):61-74. Available from: https://sid.ir/paper/193104/en

IEEE: Copy

ELHAM SIASI, Bahareh Ghane, and FATEMEH ASHRAFI, “Study of relation on breast cancer and rs3803662 polymorphism of TOX3 gene in Iranian female population by Tetra Arms PCR,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 3 , pp. 61–74, 2019, [Online]. Available: https://sid.ir/paper/193104/en

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