INVESTIGATING THE ASSOCIATION OF RS1951032 POLYMORPHISM IN THE PRE-MIR-487A FLANKING REGION WITH INCIDENCE OF BREAST CANCER IN IRANIAN WOMEN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HASHEMI R.; PEYMANI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2017 | Volume:7 | Issue:3 Page(s): 328-336

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

939

Download:

Cites:

Information Journal Paper

Title

INVESTIGATING THE ASSOCIATION OF RS1951032 POLYMORPHISM IN THE PRE-MIR-487A FLANKING REGION WITH INCIDENCE OF BREAST CANCER IN IRANIAN WOMEN

Author(s)

HASHEMI R. | PEYMANI M. | Issue Writer Certificate

Keywords

BREAST CANCERQ1

POLYMORPHISMQ2

MIRNAQ1

Abstract

Background & Objective: MIRNAs are among non-coding RNAs involved in regulation of the target genes through a direct interaction with the mRNA. Therefore, any variation in the MIRNA genes could be effective in modification of the functionality of MIRNA. The aim of the present study is to investigate the association of rs1951032 in the pre-miR-487a flanking region with incidence of BREAST CANCER in Iranian population.Materials & Methods: This case-control study was performed on 140 samples collected from 70 BREAST CANCER patients and 70 healthy participants with a similar age range. DNA extraction was performed and genotype determination was carried out by High Resolution Melting (HRM) technique. Additional confirmation was performed by sequencing of the PCR products. Finally, logistic regression analysis was used to investigate the association between the POLYMORPHISM and BREAST CANCER.Results: Statistical analysis showed a significant association between rs1951032 TC genotypes with OR=5.308 and increased incidence of mortality among patients. However, since there was no significant association between these genotypes in patients and healthy individuals, this POLYMORPHISM is not associated with the incidence of disease in individuals.Conclusions: Based on the findings of this study, rs1951032 (TC genotype) is associated with impairment in miR-487a function and biogenesis and therefore cannot suppress target gene ABCG2. Thus, rs1951032 is associated with increased incidence of mortality among patients.

Cites

No record.

References

No record.

Cite

APA: Copy

HASHEMI, R., & PEYMANI, M.. (2017). INVESTIGATING THE ASSOCIATION OF RS1951032 POLYMORPHISM IN THE PRE-MIR-487A FLANKING REGION WITH INCIDENCE OF BREAST CANCER IN IRANIAN WOMEN. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 7(3 ), 328-336. SID. https://sid.ir/paper/357908/en

Vancouver: Copy

HASHEMI R., PEYMANI M.. INVESTIGATING THE ASSOCIATION OF RS1951032 POLYMORPHISM IN THE PRE-MIR-487A FLANKING REGION WITH INCIDENCE OF BREAST CANCER IN IRANIAN WOMEN. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2017;7(3 ):328-336. Available from: https://sid.ir/paper/357908/en

IEEE: Copy

R. HASHEMI, and M. PEYMANI, “INVESTIGATING THE ASSOCIATION OF RS1951032 POLYMORPHISM IN THE PRE-MIR-487A FLANKING REGION WITH INCIDENCE OF BREAST CANCER IN IRANIAN WOMEN,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 7, no. 3 , pp. 328–336, 2017, [Online]. Available: https://sid.ir/paper/357908/en

Related Journal Papers