Evaluation of adhession and viability of endometrial stem cells-derived osteoblast-like cells cultured on PLGA/HA scaffold

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salehi mojdeh; AI JAFAR; LOTFIBAKHSHAIESH NASRIN; IRANI SHIVA; EBRAHIMI BAROUGH SOMAYEH

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:1 Page(s): 1-14

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Title

Evaluation of adhession and viability of endometrial stem cells-derived osteoblast-like cells cultured on PLGA/HA scaffold

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Keywords

Tissue EngineeringQ2

endometrial stem cellsQ2

electrospiningQ1

PLGA/HA scaffoldQ1

bone differentiationQ1

Abstract

Introduction: The engineered tissue structure includes three components: cells, signaling pathway and scaffold. The polylactide-co-glycolide/hydroxyapatite (PLGA/HA) has attracted much attention due to their optimal properties because of using PLGA polymer and hydroxyapatite. The aim of this study was to evaluate the biocompatibility effect of PLGA/HA scafffold on osteoblast differentiated from hEnSCs. We aimed to evallute the adhesin of cells on scaffolds. hEnSCs were isolated from human endometrium tissue and induced the osteogenic differentiation, then the differentiated cells were cultured on PLGA/HA synthetic scaffolds. A nanocomposite scaffolds based on PLGA/HA were fabricated by electrospinning methode and behavior of differentiated osteoblast cells was evaluated after seeding cells on this scaffold. Osteogenesis was investigated in terms of attachment, alkaline phosphatase activity and gene expression. Morphogenic of cells in scaffold was evaluated by SEM and biocampatibility of this scaffold was confirmed by MTT assay. The alkaline phosphatase activity confirmed osteoblast differentiation. SEM studies showed that the surface properties of scaffold were desirable and the cells had the ability to attach and proliferate better on the nanocomposite scaffolds. It has been shown that the nanocomposite scaffolds have appropriate properties to support the attachment of differentiated osteoblast cells.

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APA: Copy

salehi, mojdeh, AI, JAFAR, LOTFIBAKHSHAIESH, NASRIN, IRANI, SHIVA, & EBRAHIMI BAROUGH, SOMAYEH. (2019). Evaluation of adhession and viability of endometrial stem cells-derived osteoblast-like cells cultured on PLGA/HA scaffold. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(1 ), 1-14. SID. https://sid.ir/paper/193116/en

Vancouver: Copy

salehi mojdeh, AI JAFAR, LOTFIBAKHSHAIESH NASRIN, IRANI SHIVA, EBRAHIMI BAROUGH SOMAYEH. Evaluation of adhession and viability of endometrial stem cells-derived osteoblast-like cells cultured on PLGA/HA scaffold. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(1 ):1-14. Available from: https://sid.ir/paper/193116/en

IEEE: Copy

mojdeh salehi, JAFAR AI, NASRIN LOTFIBAKHSHAIESH, SHIVA IRANI, and SOMAYEH EBRAHIMI BAROUGH, “Evaluation of adhession and viability of endometrial stem cells-derived osteoblast-like cells cultured on PLGA/HA scaffold,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 1 , pp. 1–14, 2019, [Online]. Available: https://sid.ir/paper/193116/en

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