DRUG-RESISTANCE-ASSOCIATED MUTATIONS AND HIV SUB-TYPE DETERMINATION IN DRUG-NAIVE AND HIV-POSITIVE PATIENTS UNDER TREATMENT WITH ANTIRETROVIRAL DRUGS

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NAZIRI H.; TABARRAEI A.; GHAEMI A.; DAVARPANAH M.; JAVID A.; MORADI A.

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Journal: MEDICAL LABORATORY JOURNAL Year:2013 | Volume:7 | Issue:3 Page(s): 1-8

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Title

DRUG-RESISTANCE-ASSOCIATED MUTATIONS AND HIV SUB-TYPE DETERMINATION IN DRUG-NAIVE AND HIV-POSITIVE PATIENTS UNDER TREATMENT WITH ANTIRETROVIRAL DRUGS

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Keywords

HIVQ3

NUCLEOSIDE INHIBITORQ2

NON-NUCLEOSIDE INHIBITORQ2

PROTEASE INHIBITORQ2

Abstract

Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents.Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were drug-naive and the rest were under treatment for at least one year by antiretroviral agents. Virus genome was extracted from patient's plasma with high-pure-viral-nucleic-acid kit. Then, by means of reverse-transcriptase and specific primers of protease genes were amplified and sequenced. Sequences of genes, drug- antiretroviral- resistant mutations and subtypes were determined using Stanford University’s HIV-drug-resistance databases.Results: Drug-naive patients show 15% resistance to nucleoside-reverse-transcriptase inhibitor (NRTI) and 20% resistance to non-nucleoside-reverse-transcriptase inhibitor (NNRTI). Anti-protease resistance is not observed in any patients. In under treatment patients, drug resistance to NNRTI (25%) is more than drug resistance to NRTI (20%) and the rate of drug resistance to PROTEASE INHIBITOR is 5%.Conclusion: Our findings show a high prevalence of drug-resistant mutations in Iranian-drug-naive-HIV-infected patients. But in under treatment individuals, the rate of drug resistance is less than previous studies.

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APA: Copy

NAZIRI, H., TABARRAEI, A., GHAEMI, A., DAVARPANAH, M., JAVID, A., & MORADI, A.. (2013). DRUG-RESISTANCE-ASSOCIATED MUTATIONS AND HIV SUB-TYPE DETERMINATION IN DRUG-NAIVE AND HIV-POSITIVE PATIENTS UNDER TREATMENT WITH ANTIRETROVIRAL DRUGS. MEDICAL LABORATORY JOURNAL, 7(3), 1-8. SID. https://sid.ir/paper/194704/en

Vancouver: Copy

NAZIRI H., TABARRAEI A., GHAEMI A., DAVARPANAH M., JAVID A., MORADI A.. DRUG-RESISTANCE-ASSOCIATED MUTATIONS AND HIV SUB-TYPE DETERMINATION IN DRUG-NAIVE AND HIV-POSITIVE PATIENTS UNDER TREATMENT WITH ANTIRETROVIRAL DRUGS. MEDICAL LABORATORY JOURNAL[Internet]. 2013;7(3):1-8. Available from: https://sid.ir/paper/194704/en

IEEE: Copy

H. NAZIRI, A. TABARRAEI, A. GHAEMI, M. DAVARPANAH, A. JAVID, and A. MORADI, “DRUG-RESISTANCE-ASSOCIATED MUTATIONS AND HIV SUB-TYPE DETERMINATION IN DRUG-NAIVE AND HIV-POSITIVE PATIENTS UNDER TREATMENT WITH ANTIRETROVIRAL DRUGS,” MEDICAL LABORATORY JOURNAL, vol. 7, no. 3, pp. 1–8, 2013, [Online]. Available: https://sid.ir/paper/194704/en

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