DESIGN THE NEW VIRUS HTLV-1 PROTEASE PEPTIDE INHIBITORS BASED ON BENZENE FUNCTIONAL GROUP BY COMPUTATIONAL METHODS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MALEKI JAVAD; KHEIRABADI MITRA; SOUFIAN SAFIEH; SABBAGH ZADEH REIHANEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2014 | Volume:21 | Issue:4 Page(s): 637-645

Download Full-Text

Persian Verion

View:

1,319

Download:

Cites:

Information Journal Paper

Title

DESIGN THE NEW VIRUS HTLV-1 PROTEASE PEPTIDE INHIBITORS BASED ON BENZENE FUNCTIONAL GROUP BY COMPUTATIONAL METHODS

Author(s)

MALEKI JAVAD | KHEIRABADI MITRA | SOUFIAN SAFIEH | SABBAGH ZADEH REIHANEH | Issue Writer Certificate

Keywords

HTLVQ3

1Q2

PROTEASEQ2

DRUG DESIGNQ1

INHIBITORSQ1

Abstract

Background: Virus HTLV-1 is in the retrovirus family; the virus causing human diseases such as adult T-Cell Leukemia (ATL), HAM / TSP and etc… One of the major proteins in the virus is PROTEASE that is essential for virus maturation. INHIBITORS that ever made for the PROTEASE didn’t show any properly activity. We have created a new series of INHIBITORS and with using of computational tools to calculate the way of interactions to the PROTEASE protein.Materials and Methods: The compounds based on the similarity of the original peptide and based on peptidomemiticswere created. Compounds were created by software Hyperchem and optimization act on designed ligand and ligand with the protein crystal structure were performed after separating them. ADME and toxicity characteristics of the compounds were obtained by using Web applications in http://lazar-services.in-silico.ch and http://www.molinspiration.com and docking were performed on them.Results: The results of studies on ADME designed compounds already showed a good result. Toxicity studies also indicate relatively good results; also the docking results were showed good specificity.Conclusion: Our studies showed that designed INHIBITORS can be effective drug-like compounds to inhibiting the protein and therefore use to contrast with this virus.

Cites

No record.

References

No record.

Cite

APA: Copy

MALEKI, JAVAD, KHEIRABADI, MITRA, SOUFIAN, SAFIEH, & SABBAGH ZADEH, REIHANEH. (2014). DESIGN THE NEW VIRUS HTLV-1 PROTEASE PEPTIDE INHIBITORS BASED ON BENZENE FUNCTIONAL GROUP BY COMPUTATIONAL METHODS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 21(4), 637-645. SID. https://sid.ir/paper/81825/en

Vancouver: Copy

MALEKI JAVAD, KHEIRABADI MITRA, SOUFIAN SAFIEH, SABBAGH ZADEH REIHANEH. DESIGN THE NEW VIRUS HTLV-1 PROTEASE PEPTIDE INHIBITORS BASED ON BENZENE FUNCTIONAL GROUP BY COMPUTATIONAL METHODS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(4):637-645. Available from: https://sid.ir/paper/81825/en

IEEE: Copy

JAVAD MALEKI, MITRA KHEIRABADI, SAFIEH SOUFIAN, and REIHANEH SABBAGH ZADEH, “DESIGN THE NEW VIRUS HTLV-1 PROTEASE PEPTIDE INHIBITORS BASED ON BENZENE FUNCTIONAL GROUP BY COMPUTATIONAL METHODS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 4, pp. 637–645, 2014, [Online]. Available: https://sid.ir/paper/81825/en

Related Journal Papers