ASSESSMENT OF HCV INFECTION IN SUSPECTED ORPHANS NEWBORNS BY REAL-TIME PCR AND HCV-CORE AG-ELISA

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JAMALIDOUST M.; NAMAYANDEH M.; ZARE M.; ZIYAEYAN M.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2015 | Volume:5 | Issue:2 Page(s): 196-201

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Title

ASSESSMENT OF HCV INFECTION IN SUSPECTED ORPHANS NEWBORNS BY REAL-TIME PCR AND HCV-CORE AG-ELISA

Author(s)

JAMALIDOUST M. | NAMAYANDEH M. | ZARE M. | ZIYAEYAN M. | Issue Writer Certificate

Keywords

HCV INFECTIONQ2

ORPHAN NEWBORNQ2

QUANTITATIVE PCRQ2

HCV-CORE AGQ1

Abstract

Background & Objective: HCV INFECTION may be transmitted from an infected mother to her fetus in a low percentage; however, it is the most important route of infancy HCV INFECTION. The chance of HCV transmission in HIV/HCV coinfected mothers is higher than that in HCV mono-infected ones. The aim of this study is to assess HCV INFECTION status in ORPHAN NEWBORNs in Shiraz, Iran by QUANTITATIVE PCR assay and HCV core-Ag Elisa.Materials & Methods: Twenty nine HCV suspected infants, 2-7 months old, were evaluated for HCV and HIV antibodies, HCV core antigen and quantitative genome viral load.Results: Although HCV-Ab was detected in all the studied infants, HCV-RNA was not detected in plasma or Peripheral Blood Mono-Nuclear Cells (PBMCs). HIV 1, 2 Abs were not detected in none of them, either.Conclusion: A few studies have been conducted on the HCV transmission from infected mothers to their infants. According to the present results, assessment of HCV viral load and HCV core-Ag can serve as reliable tests for the prediction or exclusion of HCV INFECTION from mothers to infants.

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APA: Copy

JAMALIDOUST, M., NAMAYANDEH, M., ZARE, M., & ZIYAEYAN, M.. (2015). ASSESSMENT OF HCV INFECTION IN SUSPECTED ORPHANS NEWBORNS BY REAL-TIME PCR AND HCV-CORE AG-ELISA. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 5(2 ), 196-201. SID. https://sid.ir/paper/203895/en

Vancouver: Copy

JAMALIDOUST M., NAMAYANDEH M., ZARE M., ZIYAEYAN M.. ASSESSMENT OF HCV INFECTION IN SUSPECTED ORPHANS NEWBORNS BY REAL-TIME PCR AND HCV-CORE AG-ELISA. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2015;5(2 ):196-201. Available from: https://sid.ir/paper/203895/en

IEEE: Copy

M. JAMALIDOUST, M. NAMAYANDEH, M. ZARE, and M. ZIYAEYAN, “ASSESSMENT OF HCV INFECTION IN SUSPECTED ORPHANS NEWBORNS BY REAL-TIME PCR AND HCV-CORE AG-ELISA,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 5, no. 2 , pp. 196–201, 2015, [Online]. Available: https://sid.ir/paper/203895/en

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