EVALUATING THE EFFECT OF VITAMINS E AND C ON SEXUAL CELL LINEAGES IN ADULT MALE RATS UNDER OXIDATIVE STRESS INDUCED BY ENDOSULFAN CONSUMPTION

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HEYDARI Y.; HOSSEINI SH.; KESHAVARZ M.; MOZAFAR A.; MESHKIBAF M.H.; TAKHSHID M.A.

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Journal: Journal of Advanced Biomedical Sciences Year:2014 | Volume:4 | Issue:2 Page(s): 250-257

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Title

EVALUATING THE EFFECT OF VITAMINS E AND C ON SEXUAL CELL LINEAGES IN ADULT MALE RATS UNDER OXIDATIVE STRESS INDUCED BY ENDOSULFAN CONSUMPTION

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Keywords

ENDOSULFANQ2

VITAMINS E AND CQ2

RATQ2

SPERMATOGENESISQ2

OXIDATIVE STRESSQ2

Abstract

Background & Objective: ENDOSULFAN is one of the strong insecticides used in agriculture. This toxin is absorbed by inhalation and skin. ENDOSULFAN has side effects such as infertility in men. This study surveys the effect of VITAMINS E AND C on preventing the harmful effects of ENDOSULFAN on SPERMATOGENESIS in adult male RATs.Materials & Methods: Adult male RATs (200-250 g) from Wistar RATs were divided into five groups of 10 RATs. RATs in the experimental groups one, two, three, and four received 10 mg/kg ENDOSULFAN daily for 10 consecutive days via gavage. Moreover, during this period, RATs of group two in addition to daily ENDOSULFAN, received 20 mg / kg vitamin C daily, group three received 200mg / kg Vitamin E daily and group four received20mg / kg kg vitamin C plus 200mg / kg Vitamin E daily, by gavage. Control group received only routine food and water. At the end of this period, sexual cells were counted by light microscope on testis sections. The results were analyzed by one-way ANOVA test and Duncan's test at p≤0.05.Results: The results showed that VITAMINS E AND C have inhibitory effect on the degenerative impact of ENDOSULFAN on SPERMATOGENESIS.Conclusion: The results of this study indicated that ENDOSULFAN impairs SPERMATOGENESIS by increasing the OXIDATIVE STRESS. VITAMINS E AND C inhibit the degenerative effects of ENDOSULFAN on SPERMATOGENESIS by reducing the OXIDATIVE STRESS.

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APA: Copy

HEYDARI, Y., HOSSEINI, SH., KESHAVARZ, M., MOZAFAR, A., MESHKIBAF, M.H., & TAKHSHID, M.A.. (2014). EVALUATING THE EFFECT OF VITAMINS E AND C ON SEXUAL CELL LINEAGES IN ADULT MALE RATS UNDER OXIDATIVE STRESS INDUCED BY ENDOSULFAN CONSUMPTION. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 4(2), 250-257. SID. https://sid.ir/paper/203918/en

Vancouver: Copy

HEYDARI Y., HOSSEINI SH., KESHAVARZ M., MOZAFAR A., MESHKIBAF M.H., TAKHSHID M.A.. EVALUATING THE EFFECT OF VITAMINS E AND C ON SEXUAL CELL LINEAGES IN ADULT MALE RATS UNDER OXIDATIVE STRESS INDUCED BY ENDOSULFAN CONSUMPTION. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2014;4(2):250-257. Available from: https://sid.ir/paper/203918/en

IEEE: Copy

Y. HEYDARI, SH. HOSSEINI, M. KESHAVARZ, A. MOZAFAR, M.H. MESHKIBAF, and M.A. TAKHSHID, “EVALUATING THE EFFECT OF VITAMINS E AND C ON SEXUAL CELL LINEAGES IN ADULT MALE RATS UNDER OXIDATIVE STRESS INDUCED BY ENDOSULFAN CONSUMPTION,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 4, no. 2, pp. 250–257, 2014, [Online]. Available: https://sid.ir/paper/203918/en

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