The Anti-cancer Effects of Celastrol on K562 Cell Line

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dadakhani S.; PAZHANG YAGHUB; IMANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advanced Biomedical Sciences Year:2019 | Volume:8 | Issue:4 Page(s): 1116-1126

Download Full-Text

Persian Verion

View:

903

Download:

Cites:

Information Journal Paper

Title

The Anti-cancer Effects of Celastrol on K562 Cell Line

Author(s)

Dadakhani S. | PAZHANG YAGHUB | IMANI M. | Issue Writer Certificate

Keywords

CelastrolQ1

K562 cell lineQ1

anticancer effectsQ1

leukemiaQ3

Abstract

Background & Objective: The level of NF-κ B factor expression (a transcriptional factor which increases the expression of inflammatory genes) is often increased in various human cancers. Therefore, NF-κ B inhibitors such as Celastrol may prevent cancer development. The purpose of this study was to evaluate the anticancer effects of Celastrol on K562 cells proliferation. Materials & Methods: First, the K562 cells were cultured and cytotoxicity effects of Celastrol were determined by MTT assay. Hoechst staining and DNA electrophoresis are used to check apoptosis. Data analysis was performed using SPSS, version 16 and ANOVA test (P<0. 05) Results: Statistical analysis of MTT assay data showed that the growth of treated cells with different concentrations of the Celastrol significantly decreased (P<0. 05) and inhibitory effect of Celastrol was time and concentration– dependent; so in higher concentrations (8 μ M) and 72 hours, the maximum effect has occurred. The IC50 value of Celastrol was obtained 4 μ M. Also, the results of Hoechst staining and DNA electrophoresis showed that Celastrol caused fragmentation of cell nucleus and DNA. Conclusion: Based on the results, Celastrol decreases cells viability (P<0. 05) and induces apoptosis in K562 cells, its effect is time and dose-dependent. In conclusion, the agent may be applied as an anticancer drug for treatment of chronic myeloid leukemia.

Cites

No record.

References

No record.

Cite

APA: Copy

Dadakhani, S., PAZHANG, YAGHUB, & IMANI, M.. (2019). The Anti-cancer Effects of Celastrol on K562 Cell Line. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1116-1126. SID. https://sid.ir/paper/203976/en

Vancouver: Copy

Dadakhani S., PAZHANG YAGHUB, IMANI M.. The Anti-cancer Effects of Celastrol on K562 Cell Line. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1116-1126. Available from: https://sid.ir/paper/203976/en

IEEE: Copy

S. Dadakhani, YAGHUB PAZHANG, and M. IMANI, “The Anti-cancer Effects of Celastrol on K562 Cell Line,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1116–1126, 2019, [Online]. Available: https://sid.ir/paper/203976/en

Related Journal Papers