Investigating CpG islands Methylation in P16/Ink4 Gene Promoter Regions and the Effect of Interleukin-17 Gene Polymorphism on this Methylation in Patients with Breast Cancer

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NAEIMI SIROUS

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Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2018 | Volume:8 | Issue:1 Page(s): 628-636

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Title

Investigating CpG islands Methylation in P16/Ink4 Gene Promoter Regions and the Effect of Interleukin-17 Gene Polymorphism on this Methylation in Patients with Breast Cancer

Author(s)

NAEIMI SIROUS | Issue Writer Certificate

Keywords

PolymorphismQ2

Breast CancerQ2

IL-17Q2

MethylationQ1

P16/Ink4Q1

Abstract

Background & objective: Studies have shown that increased Methylation of CpG islands is one of the important mechanisms in gene silencing. Protein P16 / Ink4 plays an important role in the negative regulator of cell cycle process. Inflammation, including factors that affect gene Methylation and IL-17, as an inflammatory cytokine, can play a role in this case. This cytokine gene has several Polymorphisms which are involved in the expression of it. According to the statement, the purpose of this study is to investigate IL-17 gene Polymorphism on gene promoter Methylation of P16 / Ink4 and its relation to Breast Cancer diseases. Material & Methods: In this case-control study, a total of 40 Women with Breast Cancer and 40 healthy women on September 2015 were examined. DNA was extracted and for gene promoter Methylation, MSPCR method was used. Single nucleotide Polymorphisms of the IL-17 gene were analyzed by the PCR-RFLP method. Data were compared in both groups by using Pearson’ s chisquare and Hardy-Weinberg equilibrium test. Results: Results confirm the fact that, there is a relationship between P16/Ink4 gene promoter Methylation and Breast Cancer disease So that, the promoter of P16/Ink4 gene in healthy individuals was much more unmethylated than patients (p<0. 05). On the other hand there is no significant difference between IL-17 gene Polymorphisms and DAP-kinase gene Methylation (P>0. 05). Conclusion: It seems that increases of P16/Ink4 gene promoter unMethylation in control subjects is associated with the likelihood of being resistant to Breast Cancer.

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References

EPIDEMIOLOGY OF BREAST CANCER AND THE AGE DISTRIBUTION OF PATIENTS OVER A PERIOD OF TEN YEARS

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APA: Copy

NAEIMI, SIROUS. (2018). Investigating CpG islands Methylation in P16/Ink4 Gene Promoter Regions and the Effect of Interleukin-17 Gene Polymorphism on this Methylation in Patients with Breast Cancer. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(1 ), 628-636. SID. https://sid.ir/paper/204044/en

Vancouver: Copy

NAEIMI SIROUS. Investigating CpG islands Methylation in P16/Ink4 Gene Promoter Regions and the Effect of Interleukin-17 Gene Polymorphism on this Methylation in Patients with Breast Cancer. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2018;8(1 ):628-636. Available from: https://sid.ir/paper/204044/en

IEEE: Copy

SIROUS NAEIMI, “Investigating CpG islands Methylation in P16/Ink4 Gene Promoter Regions and the Effect of Interleukin-17 Gene Polymorphism on this Methylation in Patients with Breast Cancer,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 1 , pp. 628–636, 2018, [Online]. Available: https://sid.ir/paper/204044/en

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