THE ROLE OF CURCUMIN IN PROTECTION OF INDUCED TDS( TESTICULARDYSGENSIS SYNDROME ) TESTICULAR CELLS BY PHTHALATE IN MICE

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OSANLOO FATEMEH; SALEHIPOUR MASOUD; KHODARAHMI PARVIN

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2017 | Volume:7 | Issue:28 Page(s): 69-77

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Title

THE ROLE OF CURCUMIN IN PROTECTION OF INDUCED TDS( TESTICULARDYSGENSIS SYNDROME ) TESTICULAR CELLS BY PHTHALATE IN MICE

Author(s)

OSANLOO FATEMEH | SALEHIPOUR MASOUD | KHODARAHMI PARVIN | Issue Writer Certificate

Keywords

ANTI OXIDANTQ1

CURCUMINQ1

DHEAQ1

SERTOLI CELLSQ2

PHTHALATEQ1

TDSQ1

TESTOSTERONEQ1

Abstract

Aim and Background: CURCUMIN is the yellow pigment derived from rhizome of turmeric. CURCUMINoids are natural phenolsthat used in natural medicine for thousands of years. Currently antioxidant and anti-inflammatoryproperties of this material are considered in clinical practice. However, a little study that has beendone on the effect of CURCUMIN on a reproductive system. Materials and methods: This study was an experimental study, 40 male NMRI mice weighing 20 to 30 grams wereinvestigated. The rats were randomly assigned to four groups: control, treated with 10mg / kg / DayDEHP, DEHP treatment group with CURCUMIN and CURCUMIN group. After two weeks body weight ofmice were measured. Right and left testis was weighed separately. The genital pore distance (AGD)was measured. The blood was drived from the heart, TESTOSTERONE, and dehydroepiandrosteroneperformed by ELISA Mehod on mice serum. Testicular samples were cutting 5 microns and stainedwith hematoxilina-eosina method, ultimately were evaluated. Results: The study demonstrated protective effects of CURCUMIN on testis of mice. So that daily administrationDEHP10mg / kg / day with 5 ml CURCUMIN can improve the parameters of body weight (p = 0. 000), testicular right and left (p = 0. 000) and serum TESTOSTERONE (p = 0. 026) compared to mice treated withDEHP was alone. Also microscopic pathological waste, including demolition of SERTOLI CELLS andLeydig cell necrosis in the group treated with DEHP was found in the group treated with CURCUMIN +DEHP were improved. Conclusion: CURCUMIN protects testicular tissue from free radicals induced of PHTHALATEs by antioxidant properties. It also modulates the testoster hormone as a regulator of reproduction, weight and growth process.

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APA: Copy

OSANLOO, FATEMEH, SALEHIPOUR, MASOUD, & KHODARAHMI, PARVIN. (2017). THE ROLE OF CURCUMIN IN PROTECTION OF INDUCED TDS( TESTICULARDYSGENSIS SYNDROME ) TESTICULAR CELLS BY PHTHALATE IN MICE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 7(28 ), 69-77. SID. https://sid.ir/paper/204489/en

Vancouver: Copy

OSANLOO FATEMEH, SALEHIPOUR MASOUD, KHODARAHMI PARVIN. THE ROLE OF CURCUMIN IN PROTECTION OF INDUCED TDS( TESTICULARDYSGENSIS SYNDROME ) TESTICULAR CELLS BY PHTHALATE IN MICE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2017;7(28 ):69-77. Available from: https://sid.ir/paper/204489/en

IEEE: Copy

FATEMEH OSANLOO, MASOUD SALEHIPOUR, and PARVIN KHODARAHMI, “THE ROLE OF CURCUMIN IN PROTECTION OF INDUCED TDS( TESTICULARDYSGENSIS SYNDROME ) TESTICULAR CELLS BY PHTHALATE IN MICE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 7, no. 28 , pp. 69–77, 2017, [Online]. Available: https://sid.ir/paper/204489/en

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