THE EFFECT OF 14-WEEK ENDURANCE TRAINING ON LEFT VENTRICLE HDAC4 GENE EXPRESSION OF WISTAR MALE RAT

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FATHI M.; GHARAKANLOU R.; REZAEI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: SPORT AND BIOMOTOR SCIENCES Year:2014 | Volume:6 | Issue:1 (11) Page(s): 5-15

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Title

THE EFFECT OF 14-WEEK ENDURANCE TRAINING ON LEFT VENTRICLE HDAC4 GENE EXPRESSION OF WISTAR MALE RAT

Author(s)

FATHI M. | GHARAKANLOU R. | REZAEI R. | Issue Writer Certificate

Keywords

HDAC4 GENEQ2

ENDURANCE TRAININGQ2

HEARTQ1

LEFT VENTRICLEQ1

Abstract

Background; ENDURANCE TRAINING induce cardiac hypertrophy, also the cardiac hypertrophy effect on HDAC4 GENE expression in cardiac muscle, Therefore the aim of this study was to investigate the effect of ENDURANCE TRAINING on cardiac expression of HDAC4 GENE.Material and Methods; for this purpose, 14 rats (113±20 gram) under controlled conditions (temperature, light/dark (12: 12) cycle, with ad Libitum access to food and water) were housed. after familiarization (231±24) there were randomly divided into control (n=7) and Experimental (n=7) groups, the experimental group performed a training program (30 m/min, 50 min, 6 session per week for 14-weeks) on motorized treadmill, and then 48 hours after the end of the last session with control group were anesthetized as sacrificed, then the LEFT VENTRICLE of the HEART was removed. Real time RT-PCR method was used to determine of expression levels of HDAC4 GENE, finally, to compare of control and experimental groups mean, t-test was use.Results; the hypertrophy evaluation indexes showed that the ratio of LEFT VENTRICLE weight of experimental group (2.3) was significantly (P=0.05) more than control group (2.049) and the LEFT VENTRICLE weight to body surface area was significantly (p=0.01) more in experimental group (0.168) than control group (0.153). Finally the mean of LEFT VENTRICLE HDAC4 GENE expression was significantly (P=.002) higher in experimental group than control group.Conclusion; It seems the effect of ENDURANCE TRAINING on LEFT VENTRICLE accompany with increase of HDAC4 GENE expression and this increase induce by transcription factors that attached to HDAC4 GENE promoter and it increase HDAC4 GENE expression.

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