The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease

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NASRI S.; NASERI M.; PIRI M.; Mahmoudinia f.

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Journal: JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE Year:2018 | Volume:9 | Issue:1 (33) Page(s): 37-45

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Title

The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease

Author(s)

NASRI S. | NASERI M. | PIRI M. | Mahmoudinia f. | Issue Writer Certificate

Keywords

AlzheimerQ1

StreptozotocinQ2

Cyperus rotundusQ2

Memory and LearningQ2

Shuttle BoxQ2

Y-MazeQ2

Abstract

Background and Purpose: Alzheimer’ s disease is one of the most important neurodegenerative diseases resulting in free radicals and oxidative stress production. Since Cyperus rotundus plant contains anti-oxidant components, the effects of Cyperus rotundus tuber hydroalcoholic extract on learning and memory improvement in the Alzheimer model rats was investigated. Methods and Materials: In this experimental research, Intracerebroventricular Streptozotocin injection in the rats created a suitable model of Alzheimer. Rats were divided into 7 groups: control, sham, Alzheimer, Alzheimer + extract treated, and normal + extract treated groups. Treated groups received the extract with dosages of 100 and 200 mg/kg in 21 days. The rate of rat's learning and spatial memory was investigated using passive avoidance learning and Y-Maze methods. Results: In the rate of IL (Initial Latency), there was no difference between groups (p>0. 001). There is a different meaning in the rate of STL (Step through Latency) between different groups (p<0. 001). Considering the Y-Maze examination, there was no significant difference between the groups (p>0. 001). Conclusion: Results of STZ injection showed significant decrease in Memory and Learning. Treatment with Cyperus rotundus extract could increase the capability of consolidation and recall.

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APA: Copy

NASRI, S., NASERI, M., PIRI, M., & Mahmoudinia, f.. (2018). The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease. JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE, 9(1 (33) ), 37-45. SID. https://sid.ir/paper/208029/en

Vancouver: Copy

NASRI S., NASERI M., PIRI M., Mahmoudinia f.. The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease. JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE[Internet]. 2018;9(1 (33) ):37-45. Available from: https://sid.ir/paper/208029/en

IEEE: Copy

S. NASRI, M. NASERI, M. PIRI, and f. Mahmoudinia, “The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease,” JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE, vol. 9, no. 1 (33) , pp. 37–45, 2018, [Online]. Available: https://sid.ir/paper/208029/en

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