ASSESSMENT OF THE RELATIONSHIP BETWEEN CLINICAL DYSFUNCTION AND SEVERITY OF RADIOLOGIC SIGNS IN HEMOPHILIC PATIENTS IN ISFAHAN

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SIROUS M.; JAVDAN M.; NASR ESFAHANI H.; MOHSENI GH.R.

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Journal: Journal of Kermanshah University of Medical Sciences Year:2008 | Volume:12 | Issue:3 (38) Page(s): 263-270

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Title

ASSESSMENT OF THE RELATIONSHIP BETWEEN CLINICAL DYSFUNCTION AND SEVERITY OF RADIOLOGIC SIGNS IN HEMOPHILIC PATIENTS IN ISFAHAN

Author(s)

SIROUS M. | JAVDAN M. | NASR ESFAHANI H. | MOHSENI GH.R. | Issue Writer Certificate

Keywords

HEMOPHILIAQ3

ARTHROPATHYQ3

HEMARTHROSISQ3

CLINICAL DYSFUNCTIONQ3

Abstract

Introduction: HEMOPHILIA is a hereditary disease with intraarticular hemorrhage as the most common manifestation of it. Having taken into consideration the progressive articular degeneration, individual dysfunction, need for medical and surgical treatment, great cost to the patients, and also legal problems brought about by HEMOPHILIA patients’ dysfunction, this study examines the relationship between CLINICAL DYSFUNCTION and radiologic signs in hemophilic patients.Materials and Methods: This cross sectional study included 236 hemophilic patients admitted to Seyed Al Shohada hospital in Isfahan during 2001. They were all examined clinically by an orthopaedic and rediologically by a radiologists. Articular symptoms, radiologic signs, age and level of hemophilic factor were assessed. Data were then analyzed using Kruskil - Walis and Chi-square tests.Results: %45 of the patients did not show any radiologic signs. In terms of articular involvement, 6% were in stage I and %8.5 were in stage II. While the figure for stage III was %11.8, stage IV and V had 22% and 6.7% of the patients respectively. CLINICAL DYSFUNCTION was mild in 54.6%, moderate in 32.6% and severe in.8% of the patients. The least severity of radiologic involvement was seen in patients under 3 years of age with the highest in patients more than 16 years old. The most common joints involved were knee 37%, elbow 25%, ankle 22%, wrist 7.4%, shoulder 6.2%, and hip 2.4% respectively. In addition, the lower level of factor VIII, was associated with higher severity of articular involvement (P<0.001).Conclusion: This study shows that about 72% of hemophilic patients were radiologically normal or had reversible problems. The articular lesions could be prevented by immediate injection of coagulation factors and keeping the level of factor VIII at normal range. The lower level of factor VIII was associated with rebleeding and higher severity of articular involvement. It was demonstrated that articular involvement becomes more severe with aging. However, in severe cases, there was no statistical relationship between severity of radiologic articular involvement and individual dysfunction (rate of articular dysfunction). This means that hemophilic dysfunction cannot be prevented through radiology. Therefore radiology is not a useful method for screening patients with dysfunction.

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APA: Copy

SIROUS, M., JAVDAN, M., NASR ESFAHANI, H., & MOHSENI, GH.R.. (2008). ASSESSMENT OF THE RELATIONSHIP BETWEEN CLINICAL DYSFUNCTION AND SEVERITY OF RADIOLOGIC SIGNS IN HEMOPHILIC PATIENTS IN ISFAHAN. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 12(3 (38)), 263-270. SID. https://sid.ir/paper/20903/en

Vancouver: Copy

SIROUS M., JAVDAN M., NASR ESFAHANI H., MOHSENI GH.R.. ASSESSMENT OF THE RELATIONSHIP BETWEEN CLINICAL DYSFUNCTION AND SEVERITY OF RADIOLOGIC SIGNS IN HEMOPHILIC PATIENTS IN ISFAHAN. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2008;12(3 (38)):263-270. Available from: https://sid.ir/paper/20903/en

IEEE: Copy

M. SIROUS, M. JAVDAN, H. NASR ESFAHANI, and GH.R. MOHSENI, “ASSESSMENT OF THE RELATIONSHIP BETWEEN CLINICAL DYSFUNCTION AND SEVERITY OF RADIOLOGIC SIGNS IN HEMOPHILIC PATIENTS IN ISFAHAN,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 12, no. 3 (38), pp. 263–270, 2008, [Online]. Available: https://sid.ir/paper/20903/en

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