THE EFFECT OF OMEPRAZOL AND RANITIDINE ON GASTRIC ACIDITY IN ICU PATIENTS

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SALIMI GHOBAD; NAVABI S.J.; JANGI OSKOUEI N.

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Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2010 | Volume:13 | Issue:4 (43) Page(s): 283-289

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Title

THE EFFECT OF OMEPRAZOL AND RANITIDINE ON GASTRIC ACIDITY IN ICU PATIENTS

Author(s)

SALIMI GHOBAD | NAVABI S.J. | JANGI OSKOUEI N. | Issue Writer Certificate

Keywords

STRESSQ3

ULCERQ3

PROPHYLAXISQ3

ORAL OMEPERAZOQ3

L RANITIDINEQ3

GASTRICQ3

PHQ3

Abstract

Background: ICU patients especially those under mechanical ventilation or with a history of coagulation disorders are at the risk of STRESS ULCER development and related GI bleeding. Typically H2 blockers administration showed prophylactic role to control GASTRIC acidity. Preliminary studies have shown that administration of intravenous Omeperazol is effective. The object of this study was to compare the effect of oral rout administration of Omeprazol with intravenous Ranitidine on GASTRIC PH. Methods: In this experimental study 40 ICU patients under mechanical ventilation allocated into same conditions and matched Ranitidine and Omeprazol groups (20 subjects in each group). First group received 50 mg intravenous Ranitidine twice per day and the second group received 40 mg ORAL OMEPERAZOl once a day. The GASTRIC acidity was monitored using Chorning method. GASTRIC PH was determined before administration and three times per day after drugs administration then followed for three consequent days. Data was analysed using T-test and SPSS software. Results: The mean GASTRIC PH in the Ranitidin group was 2.07±0.79 before and 2.80±0.85 after drug administration. In the Omeperazol group GASTRIC PH was 2.01±1.52 before and 3.90±1.52 after drug administration. The ORAL OMEPERAZOl administration was significantly effective than intravenous Ranitidine administration.

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APA: Copy

SALIMI, GHOBAD, NAVABI, S.J., & JANGI OSKOUEI, N.. (2010). THE EFFECT OF OMEPRAZOL AND RANITIDINE ON GASTRIC ACIDITY IN ICU PATIENTS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 13(4 (43)), 283-289. SID. https://sid.ir/paper/20998/en

Vancouver: Copy

SALIMI GHOBAD, NAVABI S.J., JANGI OSKOUEI N.. THE EFFECT OF OMEPRAZOL AND RANITIDINE ON GASTRIC ACIDITY IN ICU PATIENTS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2010;13(4 (43)):283-289. Available from: https://sid.ir/paper/20998/en

IEEE: Copy

GHOBAD SALIMI, S.J. NAVABI, and N. JANGI OSKOUEI, “THE EFFECT OF OMEPRAZOL AND RANITIDINE ON GASTRIC ACIDITY IN ICU PATIENTS,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 13, no. 4 (43), pp. 283–289, 2010, [Online]. Available: https://sid.ir/paper/20998/en

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