THE EFFECTS OF RANITIDINE LONG TERM USE ON HISTOLOGICAL STRUCTURE OF MATURE RAT TESTIS

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TAVAFI M.; TAMJIDIPOUR A.; NOORI B.; TARAHI M.J.

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Journal: Yafteh Year:2006 | Volume:7 | Issue:3-4 (26) Page(s): 19-24

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Title

THE EFFECTS OF RANITIDINE LONG TERM USE ON HISTOLOGICAL STRUCTURE OF MATURE RAT TESTIS

Author(s)

TAVAFI M. | TAMJIDIPOUR A. | NOORI B. | TARAHI M.J. | Issue Writer Certificate

Keywords

RANITIDINEQ3

SEMINIFEROUS TUBULEQ4

MORPHOMETRYQ4

Abstract

Background: Since RANITIDINE inhibits the activity of testis Na+-K+ATPase, Ca++ ATPase and Mg++ATPase enzymes, and affects estrogen metabolism in the liver and causes gynecomastia, the effects of long term use of RANITIDINE on testis were studied. Materials and Methods: In this experimental study 40 two-month aged male rats were divided into four groups (control group and 1, 2 & 3 test groups). Test groups were treated with 10, 70 & 400 mg/kg/day RANITIDINE orally for two months. Right testis of each rat excised and fixed in Buins fluid. After processing and sectioning, samples stained by H & E, PAS & Trichrom staining methods and then studied qualitatively and quantitatively. Quantitative values were assessed by Tukey test in P<0.05 with SPSS Ver.12. Findings: RANITIDINE didn’t make histological lesions in testis and had no significant effect on diameter of SEMINIFEROUS TUBULE (St) and epithelial thickness in optimal dose (10 mg/kg/day). High doses of RANITIDINE (70 & 400 mg/kg/day) led to cleft formation in St epithelium, ST epithelial cavitation, St atrophy and decreased St epithelial thickness, but didn’t change St diameter. Conclusion: long term consumption of RANITIDINE at optimal dose didn’t cause lesions in normal testis structure and didn’t show significant effects on St diameter and thickness of St epithelium.

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APA: Copy

TAVAFI, M., TAMJIDIPOUR, A., NOORI, B., & TARAHI, M.J.. (2006). THE EFFECTS OF RANITIDINE LONG TERM USE ON HISTOLOGICAL STRUCTURE OF MATURE RAT TESTIS. YAFTEH, 7(3-4 (26)), 19-24. SID. https://sid.ir/paper/80285/en

Vancouver: Copy

TAVAFI M., TAMJIDIPOUR A., NOORI B., TARAHI M.J.. THE EFFECTS OF RANITIDINE LONG TERM USE ON HISTOLOGICAL STRUCTURE OF MATURE RAT TESTIS. YAFTEH[Internet]. 2006;7(3-4 (26)):19-24. Available from: https://sid.ir/paper/80285/en

IEEE: Copy

M. TAVAFI, A. TAMJIDIPOUR, B. NOORI, and M.J. TARAHI, “THE EFFECTS OF RANITIDINE LONG TERM USE ON HISTOLOGICAL STRUCTURE OF MATURE RAT TESTIS,” YAFTEH, vol. 7, no. 3-4 (26), pp. 19–24, 2006, [Online]. Available: https://sid.ir/paper/80285/en

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