THE EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA GUMMOSA ON VISCERAL PAIN IN MICE: EXPERIMENTAL STUDY

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KERAMATI KEYVAN; ASGHARI BAGHKHEIRATI AMIR; ABDOLLAHI MOSTAFA; YAGHMAEE MARZIYE; ABDOLLAHI MORTEZA

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Journal: Journal of Anesthesiology and Pain Year:2016 | Volume:7 | Issue:1 Page(s): 30-37

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA GUMMOSA ON VISCERAL PAIN IN MICE: EXPERIMENTAL STUDY

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Keywords

FERULAQ1

VISCERAL PAINQ1

ANALGESICSQ2

Abstract

Aim and Background: There are some serious side effects such as psychological dependence, blood dyscrasia& etc subsequent to using synthetic drugs in order to treat unpleasant feeling due to VISCERAL PAIN. Based ontraditional medical care and some recent findings, FERULA gummosa is a type of herb with diverse therapeuticcharacteristics such as antibacterial, antifungal, antioxidant and anti-inflammatory effects. Evaluating palliativeeffects of FERULA gummosa on VISCERAL PAIN is the goal of this study.Methods and Materials: This experimental study was done on 40 N-MRI male mice. (36±4g). Mice weredivided randomly into control group, positive group (flunixine), treatment 1, treatment 2, and treatment 3. Thecontrol group and positive group received normal saline and flunixine (2mg/kg), respectively.The treatmentgroups (1, 2, and 3) received 25, 50, and 100 mg/kg of FERULA gummosa intra-peritoneally, respectively. The micereceived 0.6% acetic acid (10mg/kg) by injection 15 minutes after each treatment; and they were evaluated forvisceral pain induction during 30 minutes.The analgesic effect was recorded by counting the number of Writhing.Data was analyzed by SPSS statistical software using One-Way ANOVA and Tukey test with the significant levelof P<0.05.Findings: The extracts of FERULA gummosa with 25, 50, 100 mg/kg doses does not induce a significant reductionin pain response in comparison with negative control (P<0.05).Conclusions: This study confirms that FERULA gummosa has no palliative property on VISCERAL PAIN. Howeverfurther studies are needed to discover an Analgesic effect of its components.

Cites

PHYTOCHEMICAL STUDY OF METHANOLIC EXTRACT OF FERULA PERSICA WILLD. INFLORESCENCE AND ITS ANTINOCICEPTIVE EFFECT IN MALE MICE

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APA: Copy

KERAMATI, KEYVAN, ASGHARI BAGHKHEIRATI, AMIR, ABDOLLAHI, MOSTAFA, YAGHMAEE, MARZIYE, & ABDOLLAHI, MORTEZA. (2016). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA GUMMOSA ON VISCERAL PAIN IN MICE: EXPERIMENTAL STUDY. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), 7(1), 30-37. SID. https://sid.ir/paper/216414/en

Vancouver: Copy

KERAMATI KEYVAN, ASGHARI BAGHKHEIRATI AMIR, ABDOLLAHI MOSTAFA, YAGHMAEE MARZIYE, ABDOLLAHI MORTEZA. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA GUMMOSA ON VISCERAL PAIN IN MICE: EXPERIMENTAL STUDY. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)[Internet]. 2016;7(1):30-37. Available from: https://sid.ir/paper/216414/en

IEEE: Copy

KEYVAN KERAMATI, AMIR ASGHARI BAGHKHEIRATI, MOSTAFA ABDOLLAHI, MARZIYE YAGHMAEE, and MORTEZA ABDOLLAHI, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA GUMMOSA ON VISCERAL PAIN IN MICE: EXPERIMENTAL STUDY,” JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), vol. 7, no. 1, pp. 30–37, 2016, [Online]. Available: https://sid.ir/paper/216414/en

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