EVALUATION OF ANTIBACTERIAL ACTIVITY OF NEW N-PIPERAZINYL QUINOLONE DERIVATIVES WITH 1,3,4- THIADIAZOLE GROUP

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOSHAFI M.; FOROUMADI A.R.; RAJAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2002 | Volume:9 | Issue:1 Page(s): 32-37

Download Full-Text

Persian Verion

View:

1,075

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF ANTIBACTERIAL ACTIVITY OF NEW N-PIPERAZINYL QUINOLONE DERIVATIVES WITH 1,3,4- THIADIAZOLE GROUP

Author(s)

MOSHAFI M. | FOROUMADI A.R. | RAJAEI M. | Issue Writer Certificate

Keywords

QUINOLONESQ3

ANTIBACTERIAL ACTIVITYQ3

1Q4

3Q4

4- THIADIAZOLEQ4

Abstract

QUINOLONES are broad-spectrum antibacterial agents. They have many clinical uses which are increasing. QUINOLONES exert ANTIBACTERIAL ACTIVITY primarily by inhibiting bacterial DNA gyrase. The inhibition of DNA gyrase by the QUINOLONES is greatly influenced by the nature of the C-7 subsistent on the QUINOLONES molecule. Substitution of bulky functional groups is also possible in C-7 position. Furthermore, benzylthio and benzylsulfonyl-1 , 3, 4- THIADIAZOLE derivatives have ANTIBACTERIAL ACTIVITY. Accordingly, a series of N-piperazinyl at C-7 position of standard QUINOLONES structure were evaluated for their ANTIBACTERIAL ACTIVITY against gram positive and gram negative bacteria using serial dilution test in solid media. The minimum inhibitory concentration (MIC) for each derivative was recorded as microgram per milliliter and comparied with ciprofloxacin as standard drug. The results showed that ANTIBACTERIAL ACTIVITY of these compounds were higher than ciprofloxacin against tested gram positive bacteria (S.aureus, S.epidermidis, B.subtillis), though the potency against tested gram-negative bacteria (E.coli, E.aeruginosa, Kpneumoniae) was significantly less than that of QUINOLONES as control drugs. In some cases there are selective activities against gram-positive bacteria. Meanwhile compounds that have benzylthio -1, 3, 4- THIADIAZOLE attached to the piperazine group at C-7 position of the quinolone molecule had a stronger ANTIBACTERIAL ACTIVITY as compared with that of benzylsulfonyl 1,3,4- thiadiazole. Furthermore, changing the substitution on the phenyl ring had no significant difference in the spectrum of ANTIBACTERIAL ACTIVITY.

Cites

THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL

References

No record.

Cite

APA: Copy

MOSHAFI, M., FOROUMADI, A.R., & RAJAEI, M.. (2002). EVALUATION OF ANTIBACTERIAL ACTIVITY OF NEW N-PIPERAZINYL QUINOLONE DERIVATIVES WITH 1,3,4- THIADIAZOLE GROUP. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 9(1), 32-37. SID. https://sid.ir/paper/224/en

Vancouver: Copy

MOSHAFI M., FOROUMADI A.R., RAJAEI M.. EVALUATION OF ANTIBACTERIAL ACTIVITY OF NEW N-PIPERAZINYL QUINOLONE DERIVATIVES WITH 1,3,4- THIADIAZOLE GROUP. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(1):32-37. Available from: https://sid.ir/paper/224/en

IEEE: Copy

M. MOSHAFI, A.R. FOROUMADI, and M. RAJAEI, “EVALUATION OF ANTIBACTERIAL ACTIVITY OF NEW N-PIPERAZINYL QUINOLONE DERIVATIVES WITH 1,3,4- THIADIAZOLE GROUP,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 1, pp. 32–37, 2002, [Online]. Available: https://sid.ir/paper/224/en

Related Journal Papers