THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL

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GHOUTASLOU REZA; ABDOLI OSKOUEI SH.; MESRI A.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 29-32

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Title

THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL

Author(s)

GHOUTASLOU REZA | ABDOLI OSKOUEI SH. | MESRI A. | Issue Writer Certificate

Keywords

CIPROJLOXACINQ2

SENSITIVITY TESTQ2

URINARY TRACT INFECTION (UTI)Q2

Abstract

OBJECTIVES: Urinary Tract Infections (UTIs) occur commonly in pediatric population. Ciprofloxacin is a fluoroquinolone antibacterial agent and an attractive alternative for the treatment of UTI in children. Although Ciprofloxacin is widely used for treatment of UTI in adults, few data is available regarding the use of Ciprofloxacin in children. This report describes the in vitro antibacterial effect of Ciprofloxacin on common strains of urinary tract infections and compares it with other drugs. METHODS: In a prospective study, 213 bacteria were collected from patients with urinary tract infections in Microbiology Laboratory of Tabriz Pediatric Medical Center during 2003-2004. Then a suseptibility test was carried out with the use of standard disks (Kirby-Bauer method) for Ciprofloxacin and was compared with Co-trimoxasol, Nalidixic acid, Nitrofurantoin, Amikacin, Gentamicin and Ampicillin. The Mean age of patients was 4.5 years old. During 9 months 213 patients with UTI were admitted (59% female and 41% male). The number of the cultures belonging to E.coli were 169 (79%), Klebsiella pneumonia 19, Enterobacter cloacae 11, Pseudomonas aeruginosa 9, Klebsiella oxitoca 3, Proteus mirabilis 2. RESULTS: It was shown that 4.3%, 18.3%, 22.5%, 26.7%, 40%, 64.7% and 95% of the bacteria were resistant to Ciprofloxacin, Amikacin, Nalidixic acid, Nitrofurantoin, Gentamicin, Co-trimoxasol and ampicillin, respectively. According to the inhibitory effect ofCiprofloxacin on the bacterial isolations and in comparison with the other antibiotics, this study demonstrated a highly broad spectrum of Ciprofloxacin. CONCLUSION: Since the tested strains proved to be highly sensitive-to Ciprofloxacin and also based on some data about safety use of this antibiotic in children, it is possible to consider Ciprofloxacin, as a drug of choice in etiotropic therapy of children with UTI. Ciprofloxacin Resistant E.coli (4.3 %) have been developed against this antibiotic in this area.

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APA: Copy

GHOUTASLOU, REZA, ABDOLI OSKOUEI, SH., & MESRI, A.. (2005). THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL. PHARMACEUTICAL SCIENCES, -(2), 29-32. SID. https://sid.ir/paper/48717/en

Vancouver: Copy

GHOUTASLOU REZA, ABDOLI OSKOUEI SH., MESRI A.. THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):29-32. Available from: https://sid.ir/paper/48717/en

IEEE: Copy

REZA GHOUTASLOU, SH. ABDOLI OSKOUEI, and A. MESRI, “THE IN VITRO ACTIVITY OF CIPROFLOXACIN ON ISOLATED ORGANISMS FROM URINARY TRACT INFECTIONS IN A PEDIATRIC HOSPITAL,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 29–32, 2005, [Online]. Available: https://sid.ir/paper/48717/en

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