EFFECT OF L-ARGININE SUPPLEMENTATION ON NACHR RESPONSE IN SKELETAL MUSCLES TO EXHAUSTIVE ACUTE EXERCISE IN OLD RATS

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NOURSHAHI M.; REZAEI R.; AGHAJAN S.; SALEHPOR M.; KHODAGHOLI F.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2017 | Volume:9 | Issue:33 Page(s): 173-186

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Title

EFFECT OF L-ARGININE SUPPLEMENTATION ON NACHR RESPONSE IN SKELETAL MUSCLES TO EXHAUSTIVE ACUTE EXERCISE IN OLD RATS

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Keywords

NICOTINIC ACETYLCHOLINE RECEPTORQ1

L ARGININEQ1

EXHAUSTIVE ACUTE EXERCISEQ1

Abstract

The purpose of this study was to investigate the effect of L-arginine supplementation on the nAchR response in hind limb of old male rats after EXHAUSTIVE ACUTE EXERCISE. For this purpose, 32 Wistar rats (age: 22 months, weight: 380±20gr) were selected. After one week of familiarization with laboratory environment, they were randomly divided into four groups consisted of: 1) L-Arginine supplement with one session of exhaustive endurance exercise, 2) L-arginine supplement 3) exercise and 4) control group. For the supplementation groups, they consumed water containing 2.5% L-Arginine for two weeks. In the exercise day, the training groups performed an exhaustive running with 30 meters per minute speed and 5-degree incline, equivalent to approximately 75-80% of their VO2max. Immediately and four hours after exercise they anesthesia and sampling was performed from EDL and Soleus muscles. Then, for statistical analysis of the data' s, the one-way ANOVA was used. data of this study illustrate that nAchR level in L-arginine supplement, significantly was higher than control group in EDL and Soleus muscles (P<0.001). And also, nAchR level in L-Arginine supplement with exercise and exercise group was increased significantly four hours after exhaustive exercise than control group in EDL and Soleus muscles (P<0.001). The result showed that L-Arginine supplementation with exercise increased of nAchR levels in old rat. It seems L-Arginine supplementation with exercise can be an appropriate approach to decrease Sarcopenia with effect on nAchR level in old aged people.

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APA: Copy

NOURSHAHI, M., REZAEI, R., AGHAJAN, S., SALEHPOR, M., & KHODAGHOLI, F.. (2017). EFFECT OF L-ARGININE SUPPLEMENTATION ON NACHR RESPONSE IN SKELETAL MUSCLES TO EXHAUSTIVE ACUTE EXERCISE IN OLD RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 9(33 ), 173-186. SID. https://sid.ir/paper/228264/en

Vancouver: Copy

NOURSHAHI M., REZAEI R., AGHAJAN S., SALEHPOR M., KHODAGHOLI F.. EFFECT OF L-ARGININE SUPPLEMENTATION ON NACHR RESPONSE IN SKELETAL MUSCLES TO EXHAUSTIVE ACUTE EXERCISE IN OLD RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2017;9(33 ):173-186. Available from: https://sid.ir/paper/228264/en

IEEE: Copy

M. NOURSHAHI, R. REZAEI, S. AGHAJAN, M. SALEHPOR, and F. KHODAGHOLI, “EFFECT OF L-ARGININE SUPPLEMENTATION ON NACHR RESPONSE IN SKELETAL MUSCLES TO EXHAUSTIVE ACUTE EXERCISE IN OLD RATS,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 9, no. 33 , pp. 173–186, 2017, [Online]. Available: https://sid.ir/paper/228264/en

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