THE EFFECT OF RESISTANCE TRAINING WITH SKELETAL MUSCLE HYPERTROPHY ON CALCINEURIN ACTIVATION AND EXPRESSION OF IL-6 MYOKINE IN FASTTWITCH SKELETAL MUSCLE OF DIABETIC RATS

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MOLANOURI SHAMSI M.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2017 | Volume:8 | Issue:32 Page(s): 201-214

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Title

THE EFFECT OF RESISTANCE TRAINING WITH SKELETAL MUSCLE HYPERTROPHY ON CALCINEURIN ACTIVATION AND EXPRESSION OF IL-6 MYOKINE IN FASTTWITCH SKELETAL MUSCLE OF DIABETIC RATS

Author(s)

MOLANOURI SHAMSI M. | Issue Writer Certificate

Keywords

TYPE-1 DIABETESQ1

INTERLEUKIN-6Q1

CALCINEURINQ1

RESISTANCE TRAININGQ2

SKELETAL MUSCLEQ2

Abstract

The phosphatase CALCINEURIN plays a major role in physiological and pathological processes, including immune responses, neuronal plasticity, and SKELETAL MUSCLE hypertrophy. Considering the effect of this factor in calcium signaling in SKELETAL MUSCLE, the purpose of the present study was to assess CALCINEURIN activation following hypertrophic RESISTANCE TRAINING in flexor hallucis longus muscle of diabetic rats with SKELETAL MUSCLE atrophy. Rats weighing 250–280 g were divided into control, training, diabetic control and diabetic training groups. Training groups performed the training consisting of climbing a ladder (1 m) with increasing weight added to the tail in 17 sessions. The expression levels of INTERLEUKIN-6 and regulator of CALCINEURIN 1 mRNA, a CALCINEURIN activation factor, were measured in flexor halluces longus muscle using realtime PCR method. The results of this study showed that diabetes was associated with increased expression of regulator of CALCINEURIN 1 in muscles of diabetic rats (P<0.05); but RESISTANCE TRAINING decreased this factor in diabetic group. Also, diabetes was associated with increased expression of IL-6 in SKELETAL MUSCLE. RESISTANCE TRAINING could not change expression of INTERLEUKIN-6 in fast twitch SKELETAL MUSCLE. Diabetes induced SKELETAL MUSCLE atrophy in rats, but RESISTANCE TRAINING maintained SKELETAL MUSCLE mass in diabetic subjects with concurrent adjustment in regulator of CALCINEURIN 1 expression in flexor halluces longus SKELETAL MUSCLE. Also, we observed concurrent increment in expression of IL-6 and regulator of CALCINEURIN 1 in present study. It seems that RESISTANCE TRAINING could contribute to SKELETAL MUSCLE protection through adjustments in expression of these factors.

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APA: Copy

MOLANOURI SHAMSI, M.. (2017). THE EFFECT OF RESISTANCE TRAINING WITH SKELETAL MUSCLE HYPERTROPHY ON CALCINEURIN ACTIVATION AND EXPRESSION OF IL-6 MYOKINE IN FASTTWITCH SKELETAL MUSCLE OF DIABETIC RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 8(32 ), 201-214. SID. https://sid.ir/paper/228299/en

Vancouver: Copy

MOLANOURI SHAMSI M.. THE EFFECT OF RESISTANCE TRAINING WITH SKELETAL MUSCLE HYPERTROPHY ON CALCINEURIN ACTIVATION AND EXPRESSION OF IL-6 MYOKINE IN FASTTWITCH SKELETAL MUSCLE OF DIABETIC RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2017;8(32 ):201-214. Available from: https://sid.ir/paper/228299/en

IEEE: Copy

M. MOLANOURI SHAMSI, “THE EFFECT OF RESISTANCE TRAINING WITH SKELETAL MUSCLE HYPERTROPHY ON CALCINEURIN ACTIVATION AND EXPRESSION OF IL-6 MYOKINE IN FASTTWITCH SKELETAL MUSCLE OF DIABETIC RATS,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 8, no. 32 , pp. 201–214, 2017, [Online]. Available: https://sid.ir/paper/228299/en

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