DETERMINATION OF CGRP ROLE IN LIPID OXIDATION DURING ENDURANCE EXERCISE IN MALE WISTAR RATS

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SADAT HOSSEINI N.; NIKOOIE R.; MOFLEHI D.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2017 | Volume:8 | Issue:32 Page(s): 185-200

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Title

DETERMINATION OF CGRP ROLE IN LIPID OXIDATION DURING ENDURANCE EXERCISE IN MALE WISTAR RATS

Author(s)

SADAT HOSSEINI N. | NIKOOIE R. | MOFLEHI D. | Issue Writer Certificate

Keywords

CALCITONIN GENE-RELATED PEPTIDEQ1

ENDURANCE TRAININGQ2

ENERGY HOMEOSTASISQ1

FAT OXIDATIONQ1

Abstract

Energy homeostasis during exercise is a complex interaction of neuronal and hormonal inputs that are integrated at the level of the central nervous system (CNS). The aim of the present study was to investigate the role of calcitonin gene related peptide (CGRP) in FAT OXIDATION during acute exercise in male Wistar rats. Thirty animals were randomly divided into three groups: control (C; n=10), training (T; n=10) and training+CGRP (8-37) (T+CGRP8-37; n=10). The animals from T and T+CGRP8-37 groups performed a single bout of endurance exercise at 26 m/min for 60 min. Cerebrospinal fluid (CSF) and blood samples were collected immediately after exercise.The animals from T+CGRP8-37 group received CGRP (8-37) (an antagonist of CGRP receptor, 10 μg/kg; IP) before endurance exercise. CGRP concentrations in the cerebrospinal fluid and serum, FFA, and triglyceride concentrations were measured by ELISA. The difference between groups were evaluated with one-way ANOVA test and Tukey’s post-hoc test.CGRP concentrations in the cerebrospinal fluid and serum were significantly higher in the animals from T (P<0.01) and T+CGRP8-37 (P<0.01) in comparison to C group. In both trained groups, plasma levels of triglycerides significantly decreased (P<0.05) and plasma FFA was significantly higher compared to that of the animals from C group (P<0.01). At the end of the exercise, only plasma FFA concentration was significantly higher in the animals from T group compared to T+CGRP8-37 group (P<0.05). In summary, endurance exercise leads to an increase in CGRP concentrations in serum and CSF, which is a contributing factor in FFA release during ENDURANCE TRAINING.

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APA: Copy

SADAT HOSSEINI, N., NIKOOIE, R., & MOFLEHI, D.. (2017). DETERMINATION OF CGRP ROLE IN LIPID OXIDATION DURING ENDURANCE EXERCISE IN MALE WISTAR RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 8(32 ), 185-200. SID. https://sid.ir/paper/228303/en

Vancouver: Copy

SADAT HOSSEINI N., NIKOOIE R., MOFLEHI D.. DETERMINATION OF CGRP ROLE IN LIPID OXIDATION DURING ENDURANCE EXERCISE IN MALE WISTAR RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2017;8(32 ):185-200. Available from: https://sid.ir/paper/228303/en

IEEE: Copy

N. SADAT HOSSEINI, R. NIKOOIE, and D. MOFLEHI, “DETERMINATION OF CGRP ROLE IN LIPID OXIDATION DURING ENDURANCE EXERCISE IN MALE WISTAR RATS,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 8, no. 32 , pp. 185–200, 2017, [Online]. Available: https://sid.ir/paper/228303/en

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