EVALUATION THE EFFECT OF ERYTHROPOIETIN ON OSTEOPOROSIS IN A MICROGRAVITY SIMULATION MODEL

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KHOSHVAGHTI A.; NURMOHAMMADI A.; JAHANI MALEKI SH.

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Journal: Ebnesina Year:2015 | Volume:17 | Issue:1 (50) Page(s): 4-9

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Title

EVALUATION THE EFFECT OF ERYTHROPOIETIN ON OSTEOPOROSIS IN A MICROGRAVITY SIMULATION MODEL

Author(s)

KHOSHVAGHTI A. | NURMOHAMMADI A. | JAHANI MALEKI SH. | Issue Writer Certificate

Keywords

OSTEOPOROSISQ3

WEIGHTLESSNESSQ3

BONE MINERAL DENSITYQ3

ERYTHROPOIETINQ3

Abstract

Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of ERYTHROPOIETIN (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in protecting bone against microgravity-induced bone loss. The aim of the present study was to investigate the effects of EPO administration on densitometric changes of femur of rat in a Microgravity Simulation Model (MSM).Materials and methods: Twelve rats were divided into two groups: the tail-suspended control (TSC), and the tail-suspended group treated with rhEpo (TSE) (300 U/kg every 48 hours). The experiment lasted for 3 weeks. The animals were sacrificed, the right femur of each rat was removed, and BONE MINERAL DENSITY was measured for each animal.Results: BONE MINERAL DENSITY of whole femur in TSE group was significantly higher than TSC group (0.1600±003 vs. 0.1440±006, p=0.002).Conclusion: According to the results of this study, ERYTHROPOIETIN administration might have protective effects against microgravity-induced mineral loss in a rat MSM.

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APA: Copy

KHOSHVAGHTI, A., NURMOHAMMADI, A., & JAHANI MALEKI, SH.. (2015). EVALUATION THE EFFECT OF ERYTHROPOIETIN ON OSTEOPOROSIS IN A MICROGRAVITY SIMULATION MODEL. EBNESINA, 17(1 (50)), 4-9. SID. https://sid.ir/paper/228640/en

Vancouver: Copy

KHOSHVAGHTI A., NURMOHAMMADI A., JAHANI MALEKI SH.. EVALUATION THE EFFECT OF ERYTHROPOIETIN ON OSTEOPOROSIS IN A MICROGRAVITY SIMULATION MODEL. EBNESINA[Internet]. 2015;17(1 (50)):4-9. Available from: https://sid.ir/paper/228640/en

IEEE: Copy

A. KHOSHVAGHTI, A. NURMOHAMMADI, and SH. JAHANI MALEKI, “EVALUATION THE EFFECT OF ERYTHROPOIETIN ON OSTEOPOROSIS IN A MICROGRAVITY SIMULATION MODEL,” EBNESINA, vol. 17, no. 1 (50), pp. 4–9, 2015, [Online]. Available: https://sid.ir/paper/228640/en

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