Evaluation of Changes Expression of D1, mGluR1 and CD38 Genes after Electrical Kindling and Treatment with Low-Frequency Stimulation in Rats

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RANJBAR S.; KHAJEH KH.; MIRNAJAFIZADEH S.J.; DABIRMANESH B.; Khodaverdian Sh.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2020 | Volume:11 | Issue:1 Page(s): 37-43

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Title

Evaluation of Changes Expression of D1, mGluR1 and CD38 Genes after Electrical Kindling and Treatment with Low-Frequency Stimulation in Rats

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Keywords

Electrical KindlingQ1

Low-Frequency StimulationQ1

SeizureQ2

EpilepsyQ2

Abstract

Electrical Kindling is one of the most popular epileptic model techniques that cause Seizures such as temporal lobe Epilepsy. So far, various therapies have been used to treatment of Epilepsy. Among these treatments, Low-Frequency Stimulation (LFS) has been widely considered for improving effect on drugresistant Epilepsy, but its mechanism is not well understood. Since calcium entering the cytoplasm and increasing its concentration is one of the most important reasons for Seizure, metabotropic glutamate receptor (mGluR1), dopamine receptor (D1), and ADPR cyclase (CD38), which increased calcium in the cytoplasm from different pathways, were selected. With this aim that by examining the change in the expression of these receptors, we help to clarify the LFS improvement effect. In the present study, the hippocampus of rats was used and the changes in genes expression were investigated using real-time PCR technique. The expression of all selected genes increased significantly after kindling and then after the LFS the expression of all three genes was returned to sham value. Hence, one of the ways in which LFS interferes may be related to the pathway for calcium entering the cytoplasm.

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APA: Copy

RANJBAR, S., KHAJEH, KH., MIRNAJAFIZADEH, S.J., DABIRMANESH, B., & Khodaverdian, Sh.. (2020). Evaluation of Changes Expression of D1, mGluR1 and CD38 Genes after Electrical Kindling and Treatment with Low-Frequency Stimulation in Rats. JOURNAL OF BIOTECHNOLOGY, 11(1 ), 37-43. SID. https://sid.ir/paper/231195/en

Vancouver: Copy

RANJBAR S., KHAJEH KH., MIRNAJAFIZADEH S.J., DABIRMANESH B., Khodaverdian Sh.. Evaluation of Changes Expression of D1, mGluR1 and CD38 Genes after Electrical Kindling and Treatment with Low-Frequency Stimulation in Rats. JOURNAL OF BIOTECHNOLOGY[Internet]. 2020;11(1 ):37-43. Available from: https://sid.ir/paper/231195/en

IEEE: Copy

S. RANJBAR, KH. KHAJEH, S.J. MIRNAJAFIZADEH, B. DABIRMANESH, and Sh. Khodaverdian, “Evaluation of Changes Expression of D1, mGluR1 and CD38 Genes after Electrical Kindling and Treatment with Low-Frequency Stimulation in Rats,” JOURNAL OF BIOTECHNOLOGY, vol. 11, no. 1 , pp. 37–43, 2020, [Online]. Available: https://sid.ir/paper/231195/en

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