THE EFFECT OF LOW-FREQUENCY ELECTRICAL STIMULATION ON AMYGDALA-KINDLED SEIZURES IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BEHESHTI NASR S.M.; MOHAMMADZADEH M.; ZAREI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2012 | Volume:19 | Issue:3 (65) Page(s): 217-227

Download Full-Text

Persian Verion

View:

1,057

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF LOW-FREQUENCY ELECTRICAL STIMULATION ON AMYGDALA-KINDLED SEIZURES IN RAT

Author(s)

BEHESHTI NASR S.M. | MOHAMMADZADEH M. | ZAREI M. | Issue Writer Certificate

Keywords

EPILEPSYQ2

SEIZUREQ3

LOW-FREQUENCY STIMULATIONQ1

RATSQ2

Abstract

Background: LOW-FREQUENCY STIMULATION (LFS) (<5 Hz) is a suitable approach for treating SEIZUREs caused by EPILEPSY.Different patterns of LFS have different effects on epileptic SEIZUREs. Since no LFS pattern has so far been determined to have the best efficacy in SEIZURE quenching, this study investigated the effect of 60-min application of LFS on amygdalakindled SEIZUREs in rat.Materials and Methods: In this experimental study, two groups of animals (14 RATS) received twice-daily kindling stimulations after stereotactic surgery and a 1-week recovery period. In group 1 (n=6), fully kindled animals received daily kindling stimulations for four days, while in group 2 (n=8), kindled animals received LFS (1 Hz, 0.1 ms pulse duration, ½ afterdischarge threshold intensity) four times (in 24-hour intervals) exactly before kindling stimulations. Afterdischarge duration (ADD), stage 2 latency (S2L), stage 4 latency (S4L), and stage 5 duration (S5D) were recorded and compared with related control groups (the same animals that had received only kindling stimulation). Data was analyzed using repeated-measures ANOVA and post-hoc Tukey’s test for within-group comparisons and Student’s t-test for between-group comparisons.Results: The first LFS application resulted in a significant increase of S2L and S4L by 91.5% (p<0.05) and 79.5% (p<0.01) compared with control group, respectively. Four-day consecutive LFS applications decreased S5D significantly, so that the first LFS application decreased S5D by 100% (p<0.001). In the first 2 days of LFS application, ADD decreased significantly by 46.9% and 40.4% (p<0.05), respectively, relative to control.Conclusion: The results suggest that LFS application immediately before SEIZURE initiation has anticonvulsant effects.

Cites

No record.

References

No record.

Cite

APA: Copy

BEHESHTI NASR, S.M., MOHAMMADZADEH, M., & ZAREI, M.. (2012). THE EFFECT OF LOW-FREQUENCY ELECTRICAL STIMULATION ON AMYGDALA-KINDLED SEIZURES IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 19(3 (65)), 217-227. SID. https://sid.ir/paper/82636/en

Vancouver: Copy

BEHESHTI NASR S.M., MOHAMMADZADEH M., ZAREI M.. THE EFFECT OF LOW-FREQUENCY ELECTRICAL STIMULATION ON AMYGDALA-KINDLED SEIZURES IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(3 (65)):217-227. Available from: https://sid.ir/paper/82636/en

IEEE: Copy

S.M. BEHESHTI NASR, M. MOHAMMADZADEH, and M. ZAREI, “THE EFFECT OF LOW-FREQUENCY ELECTRICAL STIMULATION ON AMYGDALA-KINDLED SEIZURES IN RAT,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 3 (65), pp. 217–227, 2012, [Online]. Available: https://sid.ir/paper/82636/en

Related Journal Papers