Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety Like Behavior in Adult Male Rat

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Zalkhani Raha; MOAZEDI AHMAD ALI; Ghotbeddin Zohreh; POURMAHDI BORUJENI MAHDI

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Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2018 | Volume:21 | Issue:4 (133) Page(s): 6-17

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Information Journal Paper

Title

Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety Like Behavior in Adult Male Rat

Author(s)

Zalkhani Raha | MOAZEDI AHMAD ALI | Ghotbeddin Zohreh | POURMAHDI BORUJENI MAHDI | Issue Writer Certificate

Keywords

Sodium valproateQ1

Low frequency stimulationQ1

KindlingQ3

AnxietyQ2

Abstract

Background and Aim: Emotional disorders are prevalent in many epileptic patients. So, in this research we have studied the efficacy of two treatment of seizure on Anxiety like behavior during Kindling in adult male rat. Materials and Methods: 42 male rats were randomly divided to 6 groups: Control, Sham operation, saline-kindled and drug-kindled groups which have received saline or drug 15 minutes before Kindling stimulations, and saline-kindled-LFS or drug-kindled-LFS group which have received saline or drug 15 minutes before Kindling stimulations and LFS applied after termination of Kindling stimulations. Anxiety like behavior was assessed on the 6th day by using elevated plus maze and open field apparatus. Findings: Kindling significantly increased open arms (OAs) entries percentage, OAs exploration percentage, increasing jumping from elevated plus maze (p<0. 001) and rearing frequency in open field apparatus (p<0. 05) compare to the sham group. Sodium valproate increased OAs entries percentage and OAs exploration percentage in drug-kindled group compare to sham group (p<0. 001). But there wasn’ t any significant difference in jumping from elevated plus maze and rearing in open field compare to sham group. Also, there was no significant change in these parameters in Saline-kindled-LFS, drugkindled and drug– kindled-LFS groups. Conclusion: These findings show that Sodium valproate and LFS decrease Anxiety induced by Kindling stimulation.

Cites

The Effect of Sodium Valproate and Low Frequency Electrical Stimulation on Motor Activity During Rapid Kindling of Hippocampal CA1 Region in Adult Male Rat: An Experimental Study

References

LOW FREQUENCY ELECTRICAL STIMULATION EITHER PRIOR TO OR AFTER RAPID KINDLING STIMULATION INHIBITS THE KINDLING-INDUCED EPILEPTOGENESIS

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APA: Copy

Zalkhani, Raha, MOAZEDI, AHMAD ALI, Ghotbeddin, Zohreh, & POURMAHDI BORUJENI, MAHDI. (2018). Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety Like Behavior in Adult Male Rat. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(4 (133) ), 6-17. SID. https://sid.ir/paper/68866/en

Vancouver: Copy

Zalkhani Raha, MOAZEDI AHMAD ALI, Ghotbeddin Zohreh, POURMAHDI BORUJENI MAHDI. Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety Like Behavior in Adult Male Rat. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(4 (133) ):6-17. Available from: https://sid.ir/paper/68866/en

IEEE: Copy

Raha Zalkhani, AHMAD ALI MOAZEDI, Zohreh Ghotbeddin, and MAHDI POURMAHDI BORUJENI, “Evaluation the Efficacy of Sodium Valproate and Low Frequency Stimulation During CA1 Hippocampal Kindling on Anxiety Like Behavior in Adult Male Rat,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 4 (133) , pp. 6–17, 2018, [Online]. Available: https://sid.ir/paper/68866/en

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