THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASES IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULASION ON PERFORANT PATH KINDLED SEIZURE ACQUISITION

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SADEGH MAHDI; MIRNAJAFIZADEH S.J.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2009 | Volume:11 | Issue:1 Page(s): 1-11

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Title

THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASES IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULASION ON PERFORANT PATH KINDLED SEIZURE ACQUISITION

Author(s)

SADEGH MAHDI | MIRNAJAFIZADEH S.J. | Issue Writer Certificate

Keywords

SEIZUREQ3

EPILEPSYQ2

LOW-FREQUENCY STIMULATIONQ3

KINDLINGQ2

Abstract

Background: The use of low-frequency electrical stimulation (LFS) as a therapy for EPILEPSY is currently being studied in experimental animals and patients with EPILEPSY. In the present study, we investigated the role of serine/threonine protein phosphatases in the inhibitory effects of LFS on perforant path KINDLING acquisition.Materials and Methods: Sixty four male Wistar rats were stimulated by perforant path stimulation in a rapid KINDLING manner (6 stimulations per day). The LFS (1 Hz) was applied immediately after termination of each KINDLING stimulation. The FK506 (1mM; i.c.v.), a serine/threonine protein phosphatase PP2B inhibitor and okadaic acid (1mM;i.c.v.), a serine/threonine protein phosphatases PP1/2A inhibitor, were daily microinjected into the left ventricle 10 min before starting the stimulation protocol. A two-way ANOVA was done to compare the SEIZURE parameters of different groups. The effect of LFS on behavioral SEIZURE scores was analyzed using the nonparametric Kruskal Wallis and Mann Whitney U tests. P value less than 0.05 was considered as the level of significance.Results: Appling LFS immediately after KINDLING stimulation significantly retarded the KINDLING acquisition and delayed the expression of different kindled SEIZURE stages. In addition, LFS significantly reduced the increment of daily after-discharge duration during KINDLING development. Microinjection of neither FK506 nor okadaic acid had significant effect on the antiepileptogenic effect of LFS on KINDLING parameters.Conclusion: Our findings showed that activation of PP1/2A and PP2B, which play a critical role in LFS, induced down-regulation of synaptic strength, had no role in mediating the inhibitory effects of LFS on perforant path kindled SEIZUREs.

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APA: Copy

SADEGH, MAHDI, & MIRNAJAFIZADEH, S.J.. (2009). THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASES IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULASION ON PERFORANT PATH KINDLED SEIZURE ACQUISITION. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 11(1), 1-11. SID. https://sid.ir/paper/84318/en

Vancouver: Copy

SADEGH MAHDI, MIRNAJAFIZADEH S.J.. THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASES IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULASION ON PERFORANT PATH KINDLED SEIZURE ACQUISITION. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2009;11(1):1-11. Available from: https://sid.ir/paper/84318/en

IEEE: Copy

MAHDI SADEGH, and S.J. MIRNAJAFIZADEH, “THE ROLE OF SERINE/THREONINE PROTEIN PHOSPHATASES IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULASION ON PERFORANT PATH KINDLED SEIZURE ACQUISITION,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 11, no. 1, pp. 1–11, 2009, [Online]. Available: https://sid.ir/paper/84318/en

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