REVIEW: SUPPLEMENT ANTIOXIDANT ADMINISTRATION DURING RADIOTHERAPY IN CANCER, YES OR NO?

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ZAKARYAEE VALIOALLAH; HOSSEINIMEHR SEYED JALAL

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Journal: JOURNAL OF CLINICAL EXCELLENCE Year:2013 | Volume:1 | Issue:1 Page(s): 45-64

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Title

REVIEW: SUPPLEMENT ANTIOXIDANT ADMINISTRATION DURING RADIOTHERAPY IN CANCER, YES OR NO?

Author(s)

ZAKARYAEE VALIOALLAH | HOSSEINIMEHR SEYED JALAL | Issue Writer Certificate

Keywords

ANTIOXIDANTQ3

RADIOTHERAPYQ2

RADIOPROTECTIVE AGENTQ2

SIDE EFFECTQ3

Abstract

Radiotherapy is widely used for cancer treatment. In RADIOTHERAPY, free radicals and other reactive oxygen species are produced when they are passed through cells. These free radicals can interact with critical macromolecules such as DNA which is led to cell toxicity and death.Radio protective agents and ANTIOXIDANT supplements can scavenge free radicals and protect cells against toxicity induced by these toxic substances. Although free radicals produced by RADIOTHERAPY are necessary for cancer treatment, they are toxic for normal cells. It is a paradoxical effect for ANTIOXIDANT as a protective agent in normal cells or tumor cells. It is the main problem of ANTIOXIDANT co-administration in patients during RADIOTHERAPY.After reviewing clinical trials and systematic reviews about efficacy of ANTIOXIDANTs to reduce SIDE EFFECTs induced by RADIOTHERAPY in patients, it was found that ANTIOXIDANT supplements improved average survival rate and reduced SIDE EFFECTs induced by RADIOTHERAPY.Further clinical trials for more evidence for selection of ANTIOXIDANT, dosage and duration of administration are needed.

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APA: Copy

ZAKARYAEE, VALIOALLAH, & HOSSEINIMEHR, SEYED JALAL. (2013). REVIEW: SUPPLEMENT ANTIOXIDANT ADMINISTRATION DURING RADIOTHERAPY IN CANCER, YES OR NO?. JOURNAL OF CLINICAL EXCELLENCE, 1(1), 45-64. SID. https://sid.ir/paper/243965/en

Vancouver: Copy

ZAKARYAEE VALIOALLAH, HOSSEINIMEHR SEYED JALAL. REVIEW: SUPPLEMENT ANTIOXIDANT ADMINISTRATION DURING RADIOTHERAPY IN CANCER, YES OR NO?. JOURNAL OF CLINICAL EXCELLENCE[Internet]. 2013;1(1):45-64. Available from: https://sid.ir/paper/243965/en

IEEE: Copy

VALIOALLAH ZAKARYAEE, and SEYED JALAL HOSSEINIMEHR, “REVIEW: SUPPLEMENT ANTIOXIDANT ADMINISTRATION DURING RADIOTHERAPY IN CANCER, YES OR NO?,” JOURNAL OF CLINICAL EXCELLENCE, vol. 1, no. 1, pp. 45–64, 2013, [Online]. Available: https://sid.ir/paper/243965/en

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