STUDY OF PROBIOTIC EFFECT OF BIFIDOBACTERIUM BIFIDUM ON CACOII CANCER CELL LINE

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MAHMUDIASLZADEH H.; FAZELI M.; EIDI A.; SAMADI N.; JAMALIFAR H.; PARSASERESHT L.

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Journal: Journal of Molecular and Cellular Researches Year:2014 | Volume:26 | Issue:3 Page(s): 378-385

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Title

STUDY OF PROBIOTIC EFFECT OF BIFIDOBACTERIUM BIFIDUM ON CACOII CANCER CELL LINE

Author(s)

Keywords

PROBIOTICQ2

BIFIDOBACTERIUM BIFIDUMQ2

COLON CANCERQ1

CACOII CELLSQ2

Abstract

PROBIOTICs are live microbial supplements with a wide range beneficial in human life.Effect of PROBIOTIC microorganisms on human cancer is a controversial issue. In this work the inhibitory effect of the supernatant of an autochthonous isolate of BIFIDOBACTERIUM BIFIDUM on the CACOII CELLS of human colonic carcinoma was investigated. Different concentration of 100,200, and 300 ml/ml of the supernatant of the PROBIOTIC bacteria harvested at 24,48 and 72 hours of bifidobacterial growth in MRS media were applied in to the 96 well microplates each containing 8000 cells of CacoII after neutralization of the pH with 1N NaOH. The percentage of cancer cells inhibition observed ranged from 55% to 82% which obtained from 100 ml/ml (24h) and 300 ml (72h) supernatants. The inhibitory effect of the PROBIOTIC bacteria on human cancer cells seems to be concentrated dependent and not affected by neutralization.

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APA: Copy

MAHMUDIASLZADEH, H., FAZELI, M., EIDI, A., SAMADI, N., JAMALIFAR, H., & PARSASERESHT, L.. (2014). STUDY OF PROBIOTIC EFFECT OF BIFIDOBACTERIUM BIFIDUM ON CACOII CANCER CELL LINE. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 26(3), 378-385. SID. https://sid.ir/paper/248480/en

Vancouver: Copy

MAHMUDIASLZADEH H., FAZELI M., EIDI A., SAMADI N., JAMALIFAR H., PARSASERESHT L.. STUDY OF PROBIOTIC EFFECT OF BIFIDOBACTERIUM BIFIDUM ON CACOII CANCER CELL LINE. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2014;26(3):378-385. Available from: https://sid.ir/paper/248480/en

IEEE: Copy

H. MAHMUDIASLZADEH, M. FAZELI, A. EIDI, N. SAMADI, H. JAMALIFAR, and L. PARSASERESHT, “STUDY OF PROBIOTIC EFFECT OF BIFIDOBACTERIUM BIFIDUM ON CACOII CANCER CELL LINE,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 26, no. 3, pp. 378–385, 2014, [Online]. Available: https://sid.ir/paper/248480/en

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