ANALGESIC EFFECTS OF GABAPENTIN AND IBUPROFEN ON THE PAIN IN POST THERAPY OF ROOT CANAL; A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

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MESGARANI ABBAS; MIRZAIRAD SINA; MOGHADAMNIA ALI AKBAR; MAHYAR MONA; POORSATTAR BEJEH MIR ARASH; EHSANI MARYAM

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Journal: Caspian Journal of Dental Research Year:2014 | Volume:3 | Issue:2 Page(s): 8-13

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Title

ANALGESIC EFFECTS OF GABAPENTIN AND IBUPROFEN ON THE PAIN IN POST THERAPY OF ROOT CANAL; A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

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Keywords

PULPITISQ4

ROOT CANAL THERAPYQ4

IBUPROFENQ4

GABAPENTINQ4

VISUAL ANALOGUE PAIN SCALEQ4

Abstract

Introduction: Inhibiting the pain which affects both the patients and dentists is an important factor during treating dental patients. The aim of this study was to assess the analgesic effect of two medications IBUPROFEN and GABAPENTIN on the post-endodontic-therapy pain.Methods: Forty patients who need ROOT CANAL THERAPY with Visual Analog Scale (VAS)>40, participated in this double-blind randomized clinical trial study and randomly divided into two groups. The IBUPROFEN group received 800 mg IBUPROFEN 1 hour before the treatment and 400 mg at 6, 12 and 24 hours after the treatment procedure, and the other group received 600 mg GABAPENTIN 1 hour before the treatment and 300 mg at 6, 12 and 24 hours after treatment. Patients recorded the intensity of pain via VAS before treatment and every hour for the first 6 h after taking the medication and then every 6 h thereafter for a total of the 48-hour period. (Two tablets of acetaminophen codeine (325mg/20mg) were given to the patients as a rescue dose.Results: The analgesic effect of GABAPENTIN was significantly higher than IBUPROFEN in 12h (p=0.035), 24h (p<0.001), and 48 h (p=0.012) after analgesic intake. It has been also shown that both medicines had analgesic effect significantly. (p<0.0001)Conclusions: GABAPENTIN had greater analgesic effects on the sample group from 12 h until 48h after taking in comparison with IBUPROFEN so; it seems that it could be an appropriate option for postoperative pain inhibition.

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APA: Copy

MESGARANI, ABBAS, MIRZAIRAD, SINA, MOGHADAMNIA, ALI AKBAR, MAHYAR, MONA, POORSATTAR BEJEH MIR, ARASH, & EHSANI, MARYAM. (2014). ANALGESIC EFFECTS OF GABAPENTIN AND IBUPROFEN ON THE PAIN IN POST THERAPY OF ROOT CANAL; A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. CASPIAN JOURNAL OF DENTAL RESEARCH, 3(2), 8-13. SID. https://sid.ir/paper/250226/en

Vancouver: Copy

MESGARANI ABBAS, MIRZAIRAD SINA, MOGHADAMNIA ALI AKBAR, MAHYAR MONA, POORSATTAR BEJEH MIR ARASH, EHSANI MARYAM. ANALGESIC EFFECTS OF GABAPENTIN AND IBUPROFEN ON THE PAIN IN POST THERAPY OF ROOT CANAL; A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. CASPIAN JOURNAL OF DENTAL RESEARCH[Internet]. 2014;3(2):8-13. Available from: https://sid.ir/paper/250226/en

IEEE: Copy

ABBAS MESGARANI, SINA MIRZAIRAD, ALI AKBAR MOGHADAMNIA, MONA MAHYAR, ARASH POORSATTAR BEJEH MIR, and MARYAM EHSANI, “ANALGESIC EFFECTS OF GABAPENTIN AND IBUPROFEN ON THE PAIN IN POST THERAPY OF ROOT CANAL; A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL,” CASPIAN JOURNAL OF DENTAL RESEARCH, vol. 3, no. 2, pp. 8–13, 2014, [Online]. Available: https://sid.ir/paper/250226/en

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