EVALUATION OF INACTIVATION OF INTRACANAL ANTISEPTICS BY DENTIN, DEMINERALIZED DENTIN, DENTIN MATRIX AND MINERAL COMPONENT OF DENTIN

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RAZMI HASAN; ALI GHOLI M.; SADEGHI S.D.

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Journal: Journal of Dental Medicine Year:2007 | Volume:19 | Issue:4 (49) Page(s): 17-23

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Title

EVALUATION OF INACTIVATION OF INTRACANAL ANTISEPTICS BY DENTIN, DEMINERALIZED DENTIN, DENTIN MATRIX AND MINERAL COMPONENT OF DENTIN

Author(s)

RAZMI HASAN | ALI GHOLI M. | SADEGHI S.D. | Issue Writer Certificate

Keywords

DENTINQ3

ANTIBACTERIAL AGENTSQ3

INACTIVATIONQ3

Abstract

Many studies have shown that microorganisms are the main cause of pulpal diseases and the main purpose of root canal therapy is their elimination from the root canal system. Antiseptic agents are used to reduce bacteria but their antibacterial activities differ from in vivo to in vitro studies and might be inactivated by DENTIN and its components in root canal space. This study was designed to investigate the effect of DENTIN on antibacterial activity of different antimicrobial agents.Materials and Methods: In this experimental study, two ANTIBACTERIAL AGENTS (sodium hypochlorite and chlorhexidine) with different concentrations were used in four experimental groups: Group 1: DENTIN, Group 2: demineralized DENTIN with EDTA, Group 3: DENTIN matrix and Group 4: DENTIN mineral component. The species used in this study was Entrococcus faecalis. Different concentration of agents was added to mixture of each experimental group and bacteria. At the baseline and after one and 24 hours, samples were collected and cultured. After incubation period, colonies were counted. Data were analyzed by Tukey test with p<0.05 as the limit of significance.Results: 2% and 0.2% chlorhexidine, and 5% sodium hypochlorite solutions at the three studied times eliminated Entrococcus faecalis completely. 1% sodium hypochlorite eliminated all bacteria in 1h and 24 hs. Statistical analysis showed significant differences between experimental and control groups (P<0.05). Sodium 1% hypochlorite at time 0, could reduce bacteria significantly (P<0.05) but didn’t eliminate them completely.Conclusion: INACTIVATION of intracanal antiseptics was not observed in this study. As elimination of bacteria occurred, application of these ANTIBACTERIAL AGENTS is recommended in endodontic treatment. Further investigations on other ANTIBACTERIAL AGENTS, other concentrations and shorter time intervals are recommended.

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APA: Copy

RAZMI, HASAN, ALI GHOLI, M., & SADEGHI, S.D.. (2007). EVALUATION OF INACTIVATION OF INTRACANAL ANTISEPTICS BY DENTIN, DEMINERALIZED DENTIN, DENTIN MATRIX AND MINERAL COMPONENT OF DENTIN. JOURNAL OF DENTAL MEDICINE, 19(4 (49)), 17-23. SID. https://sid.ir/paper/25526/en

Vancouver: Copy

RAZMI HASAN, ALI GHOLI M., SADEGHI S.D.. EVALUATION OF INACTIVATION OF INTRACANAL ANTISEPTICS BY DENTIN, DEMINERALIZED DENTIN, DENTIN MATRIX AND MINERAL COMPONENT OF DENTIN. JOURNAL OF DENTAL MEDICINE[Internet]. 2007;19(4 (49)):17-23. Available from: https://sid.ir/paper/25526/en

IEEE: Copy

HASAN RAZMI, M. ALI GHOLI, and S.D. SADEGHI, “EVALUATION OF INACTIVATION OF INTRACANAL ANTISEPTICS BY DENTIN, DEMINERALIZED DENTIN, DENTIN MATRIX AND MINERAL COMPONENT OF DENTIN,” JOURNAL OF DENTAL MEDICINE, vol. 19, no. 4 (49), pp. 17–23, 2007, [Online]. Available: https://sid.ir/paper/25526/en

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