SJÖGREN SYNDROME-GENE THERAPY AND ITS PROSPECTIVE

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DALOOI M.R.; RAHPEYMA R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Dental Medicine Year:2003 | Volume:15 | Issue:4 (33) Page(s): 88-102

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Title

SJÖGREN SYNDROME-GENE THERAPY AND ITS PROSPECTIVE

Author(s)

DALOOI M.R. | RAHPEYMA R. | Issue Writer Certificate

Keywords

SJOGREN'S SYNDROMEQ3

PATHOGENESISQ4

GENE THERAPYQ4

Abstract

Sjögren syndrome is one of the autoimmune diseases which is characterized by lymphocytic infiltration to exocrine glands and causes keratoconjunctivitis sicca and xerostomia. Today, a large population, with a majority of women over 40, suffers from this disease and has several complications regarding oral health and reduced life quality such as severe dental caries, painful eyes, olfactory and gustatory deficiency, speech, mastication and swallowing discomforts. Unfortunately, these patients do not respond to the conventional therapies. Nowadays in medical world, which its target is basic therapy and not symptomatic one, several GENE THERAPY approaches, have gained importance in treatment of this apparently incurable diseases. Due to the facts that this disease is the second prevelant autoimmune disease, after rheumatoid arthritis, and the conventional therapies of the disease are all relative and symptomatic, researchers have insisted on the basic and causative therapy through gene transfer more than before. In the Present article, through reviewing 58 references containing recent scientific and investigatory findings it has been tried, to consider the PATHOGENESIS and conventional therapies of this syndrome. Another purpose of this study was to investigate several and potentially very effective gene transfer systems and different theraputic genes (mainly membrane water channels, ione transporter molecules, transcription factors, antifungal proteins and free radical scavengers).

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APA: Copy

DALOOI, M.R., & RAHPEYMA, R.. (2003). SJÖGREN SYNDROME-GENE THERAPY AND ITS PROSPECTIVE. JOURNAL OF DENTAL MEDICINE, 15(4 (33)), 88-102. SID. https://sid.ir/paper/25640/en

Vancouver: Copy

DALOOI M.R., RAHPEYMA R.. SJÖGREN SYNDROME-GENE THERAPY AND ITS PROSPECTIVE. JOURNAL OF DENTAL MEDICINE[Internet]. 2003;15(4 (33)):88-102. Available from: https://sid.ir/paper/25640/en

IEEE: Copy

M.R. DALOOI, and R. RAHPEYMA, “SJÖGREN SYNDROME-GENE THERAPY AND ITS PROSPECTIVE,” JOURNAL OF DENTAL MEDICINE, vol. 15, no. 4 (33), pp. 88–102, 2003, [Online]. Available: https://sid.ir/paper/25640/en

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