HUMAN PRIMARY DENTAL PULP MESENCHYMAL STEM CELLS: HISTORY AND THE ISOLATION METHODS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JABARI FARZANEH; MOHAMMADNEJAD JAVAD; YAVARI KAMAL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Dental Medicine Year:2014 | Volume:27 | Issue:3 Page(s): 184-189

Download Full-Text

Persian Verion

View:

983

Download:

Cites:

Information Journal Paper

Title

HUMAN PRIMARY DENTAL PULP MESENCHYMAL STEM CELLS: HISTORY AND THE ISOLATION METHODS

Author(s)

JABARI FARZANEH | MOHAMMADNEJAD JAVAD | YAVARI KAMAL | Issue Writer Certificate

Keywords

STEM CELLQ2

DENTAL PULPQ3

DIFFERENTIATIONQ2

TISSUE REGENERATIONQ2

Abstract

Background and Aims: In the last decade, several studies have reported the isolation of STEM CELL population from different dental sources, while their mesenchymal nature is still controversial. The aim of this study was to introduce the isolating methods for STEM CELLs from human DENTAL PULP and to determine their mesenchymal nature before DIFFERENTIATION.Material and methods: One of the best sources for STEM CELL is DENTAL PULPs tissue. DENTAL PULP STEM CELLs (DPSCs) would be the most convenient source of STEM CELLs because teeth were easy to retrieve and removed throughout life. Pulp is a specialized connective tissue including blood and lymph vessels, nerves, and the interstitial fluid. DPSCs can be found within the ‘‘cell rich zone’’ of pulp. DPSCs have been isolated for the first time in 2000 by Gronthos; these cells exhibited a DIFFERENTIATION potential for odontoblastic, adipogenic and neural cytotypes. Gronthos isolated STEM CELLs in 2 different methods: The enzymatic digestion method and second was out growth, these cells could be cryopreserved in liquid nitrogen. It has also been shown that human DPSCs can be used for complex structures such as pulp or woven bone formation in vivo.Conclusion: DPSCs originate from the cranial neural crest and have neural characteristics such as the expression of neurotrophins. Therefore, DPSCs may represent a promising source in cell therapy for neurological disorders.Characterization of these cells and determination of their potentialities in terms of specificity of regenerative response will form the foundation for development of new clinical treatment modalities, whether involving directed recruitment of the cells and seeding of STEM CELLs at sites of injury for regeneration or use of the STEM CELLs with appropriate scaffolds for tissue engineering solutions. Such approaches will provide an innovative and novel biologically based on new generation of clinical treatments for dental disease.

Cites

No record.

References

No record.

Cite

APA: Copy

JABARI, FARZANEH, MOHAMMADNEJAD, JAVAD, & YAVARI, KAMAL. (2014). HUMAN PRIMARY DENTAL PULP MESENCHYMAL STEM CELLS: HISTORY AND THE ISOLATION METHODS. JOURNAL OF DENTAL MEDICINE, 27(3), 184-189. SID. https://sid.ir/paper/25677/en

Vancouver: Copy

JABARI FARZANEH, MOHAMMADNEJAD JAVAD, YAVARI KAMAL. HUMAN PRIMARY DENTAL PULP MESENCHYMAL STEM CELLS: HISTORY AND THE ISOLATION METHODS. JOURNAL OF DENTAL MEDICINE[Internet]. 2014;27(3):184-189. Available from: https://sid.ir/paper/25677/en

IEEE: Copy

FARZANEH JABARI, JAVAD MOHAMMADNEJAD, and KAMAL YAVARI, “HUMAN PRIMARY DENTAL PULP MESENCHYMAL STEM CELLS: HISTORY AND THE ISOLATION METHODS,” JOURNAL OF DENTAL MEDICINE, vol. 27, no. 3, pp. 184–189, 2014, [Online]. Available: https://sid.ir/paper/25677/en

Related Journal Papers