EFFECT OF ENDURANCE EXERCISE TRAINING AND GALLIC ACID ON TUMOR NECROSIS FACTOR-Α IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE

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BAZYAR YUNES; RAFIEI SAMANEH; HOSSEINI ALI; EDALATMANESH MOHAMMAD AMIN

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:3 Page(s): 21-26

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Title

EFFECT OF ENDURANCE EXERCISE TRAINING AND GALLIC ACID ON TUMOR NECROSIS FACTOR-Α IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE

Author(s)

BAZYAR YUNES | RAFIEI SAMANEH | HOSSEINI ALI | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

ALZHEIMER DISEASEQ2

EXERCISEQ2

GALLIC ACIDQ3

HIPPOCAMPUSQ2

Abstract

Introduction: Alzheimer’s disease (AD) is a non-refundable gradual neuro-degenerative disorder, in which the neurons, especially the ones in the memory zone, are damaged and cause increase in the level of cytokines, such as tumor necrosis factor-a (TNF-a). In the present study, we investigated the effect of endurance EXERCISE training and chronic administration of GALLIC ACID (GA) on the TNF-a level in rat HIPPOCAMPUS in the Trimethyltin (TMT) -treated model of AD.Materials and Methods: Seventy female Spraque Dawley rats were divided into seven groups: 1.Control, 2. AD, 3. GA50, 4. GA100, 5. EXERCISE, 6. EXERCISE+GA50, and 7.Exercise+GA100. In order to induce AD, Trimethyltin (8mg/kg) was injected intraperitoneally to the rats in groups 2-7. Rats in the groups 5, 6, and 7 carried out an eight-week EXERCISE program on a motorized treadmill (15-20 m/min, 0% inclination for 15-30 min/day, and 5 days/ week). Animals of the groups 3 and 6 were treated by 50 mg/kg of GA and animals of groups 4 and 7 were treated by 100 mg/kg of the GA daily, for 2 weeks. Then, the TNF-a level in the HIPPOCAMPUS were measured.Results: The results indicated that the TNF-α level in the HIPPOCAMPUS was decreased in all test groups compared to the AD group.Conclusion: Our findings indicate that endurance EXERCISE training, GA consumption, and both administration of GA and co-treatment with training have immunomodulatory effects and could be used to inhibit the cytokine release after TMT intoxication.

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APA: Copy

BAZYAR, YUNES, RAFIEI, SAMANEH, HOSSEINI, ALI, & EDALATMANESH, MOHAMMAD AMIN. (2015). EFFECT OF ENDURANCE EXERCISE TRAINING AND GALLIC ACID ON TUMOR NECROSIS FACTOR-? IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(3), 21-26. SID. https://sid.ir/paper/257902/en

Vancouver: Copy

BAZYAR YUNES, RAFIEI SAMANEH, HOSSEINI ALI, EDALATMANESH MOHAMMAD AMIN. EFFECT OF ENDURANCE EXERCISE TRAINING AND GALLIC ACID ON TUMOR NECROSIS FACTOR-? IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(3):21-26. Available from: https://sid.ir/paper/257902/en

IEEE: Copy

YUNES BAZYAR, SAMANEH RAFIEI, ALI HOSSEINI, and MOHAMMAD AMIN EDALATMANESH, “EFFECT OF ENDURANCE EXERCISE TRAINING AND GALLIC ACID ON TUMOR NECROSIS FACTOR-? IN AN ANIMAL MODEL OF ALZHEIMER’S DISEASE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 3, pp. 21–26, 2015, [Online]. Available: https://sid.ir/paper/257902/en

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