THE EFFECT OF MK-801 ON MEMORY AFTER INDUCTION OF REPETITIVE SPREADING DEPRESSION IN THE JUVENILE RAT

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KHODAIE BABAK; LOTFINIA AHMAD ALI; LOTFINIA MAHMOUD; AHMADI MILAD; JAFARIAN MARYAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2013 | Volume:1 | Issue:4 Page(s): 22-28

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Title

THE EFFECT OF MK-801 ON MEMORY AFTER INDUCTION OF REPETITIVE SPREADING DEPRESSION IN THE JUVENILE RAT

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Keywords

CORTICAL SPREADING DEPRESSIONQ3

HIPPOCAMPUSQ3

MEMORYQ2

BRAINQ2

Abstract

Introduction: The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization linked with ionic distribution and cellular swelling. Glutamate release following cell depolarization in extracellular space is a major event in this phenomenon. The HIPPOCAMPUS is widely accepted to play a pivotal role in MEMORY. The aim of the present study was to evaluate the role of glutamate N-methyl-D-aspartate (NMDA) sub receptor on SD-induced MEMORY deficits in rats.Materials and Methods: 36 juvenile Wistar rat were used to investigate the role of repetitive SD induction on MEMORY performance by T-Maze test. We have investigated the role of MK-801, a NMDA receptor blocker, on the MEMORY retrieval by the same test.Results: Behavioral assessments showed that MEMORY retrieval significantly impaired following by the repetitive SD induction. However, application of MK-801 improved the MEMORY deficits induced by the repetitive SD.Conclusion: Our data suggested that NMDA receptors may play a critical role on protection of MEMORY in SD related disorders.

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