ASSESSMENT OF AMPA RECEPTOR ANTAGONIST ADMINISTRATION ON SPATIAL MEMORY OF JUVENILE RATS INDUCED REPETITIVE SPREADING DEPRESSION

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LOTFINIA AHMAD ALI; LOTFINIA MAHMOUD; AHMADI MILAD; KHODAIE BABAK; JAFARIAN MARYAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:1 Page(s): 56-62

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Title

ASSESSMENT OF AMPA RECEPTOR ANTAGONIST ADMINISTRATION ON SPATIAL MEMORY OF JUVENILE RATS INDUCED REPETITIVE SPREADING DEPRESSION

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Keywords

CORTICAL SPREADING DEPRESSIONQ3

RECEPTORS AMPAQ3

MEMORYQ2

Abstract

Introduction: Spreading depression (SD) is a bio-electrical wave in the central nervous system which propagates through the gray matter and cause several effects, such as neural depolarization and ionic disturbances. This phenomenon plays a role in many neurological disorders, like epilepsy, migraine with aura, brain injury and cerebrovascular disease. The SD excitatory effect of glutamate receptors on the brain seems to be correlated with neural injuries. The aim of our study was to evaluate the role of glutamate AMPA sub receptors on spatial MEMORY impairment induced by SD.Materials and Methods: DNQX, an AMPA antagonist, was administrated (1 mg/kg) intraperitoneally after SD induction (induced by application of 2 M KCl) in juvenile wistar rats (60-80 gr). Retrieval of spatial MEMORY was evaluated by T-maze MEMORY test.Results: Repetitive weekly induction of SD caused MEMORY impairment after four weeks. Blockade of AMPA receptors with DNQX did not affect the MEMORY impairment caused by SD.Conclusion: Our data indicate glutamate AMPA subreceptors are not involved in SD-induced MEMORY deficits in juvenile rats.

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APA: Copy

LOTFINIA, AHMAD ALI, LOTFINIA, MAHMOUD, AHMADI, MILAD, KHODAIE, BABAK, & JAFARIAN, MARYAM. (2014). ASSESSMENT OF AMPA RECEPTOR ANTAGONIST ADMINISTRATION ON SPATIAL MEMORY OF JUVENILE RATS INDUCED REPETITIVE SPREADING DEPRESSION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(1), 56-62. SID. https://sid.ir/paper/258098/en

Vancouver: Copy

LOTFINIA AHMAD ALI, LOTFINIA MAHMOUD, AHMADI MILAD, KHODAIE BABAK, JAFARIAN MARYAM. ASSESSMENT OF AMPA RECEPTOR ANTAGONIST ADMINISTRATION ON SPATIAL MEMORY OF JUVENILE RATS INDUCED REPETITIVE SPREADING DEPRESSION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(1):56-62. Available from: https://sid.ir/paper/258098/en

IEEE: Copy

AHMAD ALI LOTFINIA, MAHMOUD LOTFINIA, MILAD AHMADI, BABAK KHODAIE, and MARYAM JAFARIAN, “ASSESSMENT OF AMPA RECEPTOR ANTAGONIST ADMINISTRATION ON SPATIAL MEMORY OF JUVENILE RATS INDUCED REPETITIVE SPREADING DEPRESSION,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 1, pp. 56–62, 2014, [Online]. Available: https://sid.ir/paper/258098/en

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