The Role of Amnesia Caused by Cerebral Hypoperfusion on Depression-Like Behavior in Male Wis tar Rats

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DIVANBEIGI ASHKAN; NASEHI MOHAMMAD; AMIRI SEPIDEH; ZARRINDAST MOHAMMAD REZA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:8 | Issue:1 Page(s): 42-50

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Title

The Role of Amnesia Caused by Cerebral Hypoperfusion on Depression-Like Behavior in Male Wis tar Rats

Author(s)

DIVANBEIGI ASHKAN | NASEHI MOHAMMAD | AMIRI SEPIDEH | ZARRINDAST MOHAMMAD REZA | Issue Writer Certificate

Keywords

AmnesiaQ1

DementiaQ1

Brain IschemiaQ2

DepressionQ2

Abstract

Introduction: Anxiety disorders, Depression, and Dementia are common in elderly, which may overlap in various neurological disorders. Stress can be a risk factor for long-term Depression. It also sugges ts that Depression plays a role in developing Dementia. Amnesia is the mos t problem in Dementia. Is Amnesia a risk factor for Depression? Considering the common underlying mechanisms for causing these disorders, the purpose of this s tudy is to inves tigate the role of Amnesia in developing Depression. Materials and Methods: Fortyeight wis tar rats were divided into two main groups (sham-A and intervention-B) and four subgroups (Control-C, Chronic mild s tress-D, hypoperfusion without s tress-E, hypoperfusion with Mild s tress-F). Permanent occlusion of bilateral common carotid artery was performed to induce cerebral hypoperfusion. Radial arm maze tes t and chronic unpredictable mild s tress were used to evaluate Amnesia and Depression, respectively. Forced swim tes t was performed to assess severity of Depression and finally we used neuronal count for evaluating cellular degeneration in the CA1 hippocampus region. Results: Cerebral hypoperfusion causes Amnesia and significantly reduced the mean number of cells in the hippocampal CA1 area. Cerebral hypoperfusion and s tress significantly increased the incidence of Depression-like behavior. Conclusion: Amnesia caused by cerebral hypoperfusion can increase the risk of Depression, especially under s tressful situations.

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APA: Copy

DIVANBEIGI, ASHKAN, NASEHI, MOHAMMAD, AMIRI, SEPIDEH, & ZARRINDAST, MOHAMMAD REZA. (2020). The Role of Amnesia Caused by Cerebral Hypoperfusion on Depression-Like Behavior in Male Wis tar Rats. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 8(1 ), 42-50. SID. https://sid.ir/paper/257941/en

Vancouver: Copy

DIVANBEIGI ASHKAN, NASEHI MOHAMMAD, AMIRI SEPIDEH, ZARRINDAST MOHAMMAD REZA. The Role of Amnesia Caused by Cerebral Hypoperfusion on Depression-Like Behavior in Male Wis tar Rats. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2020;8(1 ):42-50. Available from: https://sid.ir/paper/257941/en

IEEE: Copy

ASHKAN DIVANBEIGI, MOHAMMAD NASEHI, SEPIDEH AMIRI, and MOHAMMAD REZA ZARRINDAST, “The Role of Amnesia Caused by Cerebral Hypoperfusion on Depression-Like Behavior in Male Wis tar Rats,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 8, no. 1 , pp. 42–50, 2020, [Online]. Available: https://sid.ir/paper/257941/en

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