Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin

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DAVOODIAN NAJMEH; Khetvan Hafshejani Reza; KADIVAR ALI; MODARRES MOUSAVI SAYED MOSTAFA; Aali Ehsan; Gheami Amir; Bakhtiari Moghaddam Behnam; SHIRIAN SADEGH

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Journal: Neuroscience Journal of Shefaye Khatam Year:2019 | Volume:7 | Issue:3 Page(s): 74-90

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Title

Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin

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NeuroendocrinologyQ1

FertilityQ1

MelatoninQ2

MaleQ1

GonadotropinsQ1

Abstract

Introduction: A subset of neurons has been recently identified in the arcuate nucleus of the hypothalamus that co-localize three neuropeptides; kisspeptin, neurokinin B, and dynorphin (KNDy). These neuropeptides have been shown to play a critical role in the central control of reproduction and the modulation of gonadotrophin releasing hormone (GnRH) secretion by endocrine, metabolic and environmental inputs. KNDy also acts as a novel potential therapeutic target in the treatment of Fertility disorders. InFertility following chemotherapy is particularly common in Male survivors of childhood cancer and for tes ticular cancer survivors. Early human s tudies have sugges ted that peripheral exogenous Kisspeptin adminis tration s timulates GnRH secretion in healthy adults and in patients with some forms of inFertility. In this review, we describe our current unders tanding of the neural sys tems mediating the actions of KNDy neurons on GnRH pulse generation and Male Fertility. In addition, the effect of Melatonin treatment on the GnRH neuronal sys tem and its effect on kisspeptin and gonadotropin-inhibitory neurons are discussed. Conclusion: Further researches about functional and molecular mechanisms of KNDy pathway, endogenous opioid peptide, and antioxidant agents, such as Melatonin, may develop novel approaches to treat chemotherapy induced-inFertility in Males.

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APA: Copy

DAVOODIAN, NAJMEH, Khetvan Hafshejani, Reza, KADIVAR, ALI, MODARRES MOUSAVI, SAYED MOSTAFA, Aali, Ehsan, Gheami, Amir, Bakhtiari Moghaddam, Behnam, & SHIRIAN, SADEGH. (2019). Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(3 ), 74-90. SID. https://sid.ir/paper/258057/en

Vancouver: Copy

DAVOODIAN NAJMEH, Khetvan Hafshejani Reza, KADIVAR ALI, MODARRES MOUSAVI SAYED MOSTAFA, Aali Ehsan, Gheami Amir, Bakhtiari Moghaddam Behnam, SHIRIAN SADEGH. Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(3 ):74-90. Available from: https://sid.ir/paper/258057/en

IEEE: Copy

NAJMEH DAVOODIAN, Reza Khetvan Hafshejani, ALI KADIVAR, SAYED MOSTAFA MODARRES MOUSAVI, Ehsan Aali, Amir Gheami, Behnam Bakhtiari Moghaddam, and SADEGH SHIRIAN, “Neuroendocrine Role of Kisspeptin-Neurokinin B-Dynorphin Pathway in Male Fertility and its Correlation with Melatonin,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 3 , pp. 74–90, 2019, [Online]. Available: https://sid.ir/paper/258057/en

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