THE EFFECT OF SPREADING DEPRESSION ON GLYCOCONJUGATES OF DENTATE GYRUS IN RATS

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JAFARIAN MARYAM; KARIMZADEH FARIBA; RAHIMI SADEGH; HOSSEINI SEYED MAHMOUD; MOHAMMADZADEH ELHAM; FAZEL ALIREZA

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Title

THE EFFECT OF SPREADING DEPRESSION ON GLYCOCONJUGATES OF DENTATE GYRUS IN RATS

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Keywords

CORTICAL SPREADING DEPRESSIONQ3

DENTATE GYRUSQ4

LECTINSQ4

Abstract

Introduction: Spreading depression (SD) is a pathophysiological phenomenon caused by repetitive depolarization of neurons and glial cells. There is a relationship between SD and some disorders, such as migraine with aura. Glycoconjugates play an important role in cell proliferation and differentiation. It has been shown that SD can stimulate the neurogenesis. In the present study, the effect of SD on expressing and distribution of glycoconjugates was evaluated.Materials & Methods: Forty rats (30-45 days) were divided into two groups: 1 week and 1 month each group was contained three subgroups: control, sham and SD. Two and four SD was induced by KCL injection in 1 week and 1 month groups, respectively. Histochemical studies were performed by using five different horse radish peroxidase labeled LECTINS, including PNA, VVA, MPA and LTA in polymorph layer of hippocampal DENTATE GYRUS.Results: There were no differences in the expression of three LECTINS (PNA, VVA, and MPA) in all different groups. However, induction of SD significantly enhanced the expression of LTA compared with sham and control groups.Conclusion: Higher intensity reaction of LTA indicates a possible role of L-focuses monosaccharide in changes of synaptic plasticity induced by SD.

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APA: Copy

JAFARIAN, MARYAM, KARIMZADEH, FARIBA, RAHIMI, SADEGH, HOSSEINI, SEYED MAHMOUD, MOHAMMADZADEH, ELHAM, & FAZEL, ALIREZA. (2013). THE EFFECT OF SPREADING DEPRESSION ON GLYCOCONJUGATES OF DENTATE GYRUS IN RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 1(1), 31-36. SID. https://sid.ir/paper/258063/en

Vancouver: Copy

JAFARIAN MARYAM, KARIMZADEH FARIBA, RAHIMI SADEGH, HOSSEINI SEYED MAHMOUD, MOHAMMADZADEH ELHAM, FAZEL ALIREZA. THE EFFECT OF SPREADING DEPRESSION ON GLYCOCONJUGATES OF DENTATE GYRUS IN RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2013;1(1):31-36. Available from: https://sid.ir/paper/258063/en

IEEE: Copy

MARYAM JAFARIAN, FARIBA KARIMZADEH, SADEGH RAHIMI, SEYED MAHMOUD HOSSEINI, ELHAM MOHAMMADZADEH, and ALIREZA FAZEL, “THE EFFECT OF SPREADING DEPRESSION ON GLYCOCONJUGATES OF DENTATE GYRUS IN RATS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 1, no. 1, pp. 31–36, 2013, [Online]. Available: https://sid.ir/paper/258063/en

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