EVALUATION OF THE NEUROTROPHIC FACTORS IN ANIMAL MODEL OF MYELIN DESTRUCTION INDUCED BY CUPRIZONE IN C57BL/6 MICE

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SHIRAZI AREFEH; GOLAB FERESHTEH; SANADGOL NIMA; BARATI MAHMOOD; MOHAMMAD SALEHI REZA; VAHABZADEH GELAREH; SHADALUI ZEINAB; REZAEI ZARCHI SAEED

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:2 Page(s): 47-54

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Title

EVALUATION OF THE NEUROTROPHIC FACTORS IN ANIMAL MODEL OF MYELIN DESTRUCTION INDUCED BY CUPRIZONE IN C57BL/6 MICE

Author(s)

Keywords

MULTIPLE SCLEROSISQ2

NERVE GROWTH FACTORSQ3

CUPRIZONEQ2

Abstract

Introduction: MULTIPLE SCLEROSIS (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with unknown etiology. Neurotrophins are polypeptides belonging to the neurotrophic factor family. Neurotrophins mediate cell survival and proliferation in the nervous system. In this study, we determined the production of various neurotrophins, including brainderived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and glial cell-derived neurotrophic factor (GDNF) in CUPRIZONE model of demyelination.Materials and Methods: In order to induce demyelination, animals were treated by CUPRIZONE. The mice were divided into three groups. The first group was treated by CUPRIZONE for 5 weeks. The second group was treated by CUPRIZONE for 5 weeks and normal diet for 1 week. The third (control) group received normal diet for 6 weeks. After the mice were sacrificed, cerebral corpus callosum was removed and evaluated for expression of neurotrophic factors by real time PCR and histological evaluation.Results: After five weeks, we detected a significant increase of BDNF and GDNF compared to the control group. No changes were observed in CNTF expression. After six weeks, expression of BDNF and GDNF were decreased but they had still higher levels compared to control group.Conclusion: This study suggests that neurotrophins may play a role in pathogenesis of MS.

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References

NEUROTROPHIC FACTORS AND THEIR EFFECTS IN THE TREATMENT OF MULTIPLE SCLEROSIS

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APA: Copy

SHIRAZI, AREFEH, GOLAB, FERESHTEH, SANADGOL, NIMA, BARATI, MAHMOOD, MOHAMMAD SALEHI, REZA, VAHABZADEH, GELAREH, SHADALUI, ZEINAB, & REZAEI ZARCHI, SAEED. (2016). EVALUATION OF THE NEUROTROPHIC FACTORS IN ANIMAL MODEL OF MYELIN DESTRUCTION INDUCED BY CUPRIZONE IN C57BL/6 MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(2), 47-54. SID. https://sid.ir/paper/258076/en

Vancouver: Copy

SHIRAZI AREFEH, GOLAB FERESHTEH, SANADGOL NIMA, BARATI MAHMOOD, MOHAMMAD SALEHI REZA, VAHABZADEH GELAREH, SHADALUI ZEINAB, REZAEI ZARCHI SAEED. EVALUATION OF THE NEUROTROPHIC FACTORS IN ANIMAL MODEL OF MYELIN DESTRUCTION INDUCED BY CUPRIZONE IN C57BL/6 MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(2):47-54. Available from: https://sid.ir/paper/258076/en

IEEE: Copy

AREFEH SHIRAZI, FERESHTEH GOLAB, NIMA SANADGOL, MAHMOOD BARATI, REZA MOHAMMAD SALEHI, GELAREH VAHABZADEH, ZEINAB SHADALUI, and SAEED REZAEI ZARCHI, “EVALUATION OF THE NEUROTROPHIC FACTORS IN ANIMAL MODEL OF MYELIN DESTRUCTION INDUCED BY CUPRIZONE IN C57BL/6 MICE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 2, pp. 47–54, 2016, [Online]. Available: https://sid.ir/paper/258076/en

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