MITOCHONDRIAL DEFECTS AND OXIDATIVE STRESS IN ALZHEIMER DISEASE

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BABAEI ABRAKI SHAHNAZ; CHAVOSHI NEZHAD SARA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:1 Page(s): 85-94

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Information Journal Paper

Title

MITOCHONDRIAL DEFECTS AND OXIDATIVE STRESS IN ALZHEIMER DISEASE

Author(s)

BABAEI ABRAKI SHAHNAZ | CHAVOSHI NEZHAD SARA | Issue Writer Certificate

Keywords

ANTIOXIDANTSQ3

ALZHEIMER DISEASEQ2

OXIDATIVE STRESSQ2

FREE RADICALSQ3

REACTIVE OXYGEN SPECIESQ3

Abstract

Introduction: ALZHEIMER DISEASE (AD) is the most common age-related neurodegenerative disease characterized by extracellular amyloid-b (Ab) plaques and intracellular neurofibrillary tangles containing hyper-phosphorylated tau. As an important molecule in the pathogenesis of AD, Ab interferes with multiple aspects of mitochondrial function, including energy metabolism failure, production of REACTIVE OXYGEN SPECIES (ROS) and permeability transition pore formation. Recent studies have demonstrated that Ab progressively accumulates within mitochondrial matrix and provides a direct link to mitochondrial toxicity. Convincing evidence demonstrates mitochondria as a crucial organel in ROS generation and links OXIDATIVE STRESS to the development of neuronal dysfunction and death, which suggests a key pathogenic role for OXIDATIVE STRESS in AD. In this review, we focus on changes in mitochondrial defects and OXIDATIVE STRESS in the pathogenesis of AD. Interaction of AD with Ab exaggerates Ab-mediated mitochondrial and neuronal perturbation, leading to impaired synaptic function and memory.Conclusion: Blockade of ROS generation may be a potential therapeutic strategy for treatment of AD.

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APA: Copy

BABAEI ABRAKI, SHAHNAZ, & CHAVOSHI NEZHAD, SARA. (2014). MITOCHONDRIAL DEFECTS AND OXIDATIVE STRESS IN ALZHEIMER DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(1), 85-94. SID. https://sid.ir/paper/258092/en

Vancouver: Copy

BABAEI ABRAKI SHAHNAZ, CHAVOSHI NEZHAD SARA. MITOCHONDRIAL DEFECTS AND OXIDATIVE STRESS IN ALZHEIMER DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(1):85-94. Available from: https://sid.ir/paper/258092/en

IEEE: Copy

SHAHNAZ BABAEI ABRAKI, and SARA CHAVOSHI NEZHAD, “MITOCHONDRIAL DEFECTS AND OXIDATIVE STRESS IN ALZHEIMER DISEASE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 1, pp. 85–94, 2014, [Online]. Available: https://sid.ir/paper/258092/en

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