COMPARING THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON SERUM OXIDATIVE STRESS FACTORS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Darbandi Niloufar; MOGHADASI SAMIRA; MOMENI HAMID REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:3 Page(s): 206-221

Download Full-Text

Persian Verion

View:

1,174

Download:

Cites:

Information Journal Paper

Title

COMPARING THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON SERUM OXIDATIVE STRESS FACTORS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS

Author(s)

Darbandi Niloufar | MOGHADASI SAMIRA | MOMENI HAMID REZA | Issue Writer Certificate

Keywords

ACUTE AND CHRONIC METFORMINQ1

SERUM OXIDATIVE STRESS FACTORSQ1

STREPTOZOTOCINQ2

Abstract

Introduction: Studies have indicated that metformine has different effects on learning and memory. In this study, both acute and chronic therapeutic effects of metformin on memory retrieval and some SERUM OXIDATIVE STRESS FACTORS in STREPTOZOTOCIN -induced Alzheimeric male rats were investigated. Methods: In this experimental study, 48 rats were divided into six groups (n=8) as follows: saline - saline, STREPTOZOTOCIN - saline, and STREPTOZOTOCIN - metformine (once, one week, three weeks and eleven weeks). Intracerebroventricular administrations of STREPTOZOTOCIN (3 mg/kg) were done at the first and third day of the surgery. Intraperitoneally administrations of saline (ml/kg) or metformin (200 mg/kg) was started one day before the surgery and continued until the end of the care period. The animals’ memory was evaluated through passive avoidance learning; blood serums were used to measure the levels of malondialdehyde, assessment of Ferric Reducing Ability of Plasma (FRAP), levels of superoxide dismutase and catalase enzymes.Results: STREPTOZOTOCIN (STZ) significantly reduced the memory retrieval and the levels of FRAP, superoxide dismutase and catalase enzymes and it significantly increased the level of malondialdehyde compared to the control group (p<0.001). Administration of metformin (once, one week and three weeks) improved the memory retrieval and SERUM OXIDATIVE STRESS FACTORS compared to the STZ group (p<0.001). While the administration of metformin in eleven weeks group did not have any significantly differences compared to the STZ group (p>0.05).Conclusion: It seems that administration of ACUTE AND CHRONIC METFORMIN has different effects on the memory retrieval that it may be due to the effect of chronic metformin in increasing the level of oxidative stress factors in serum.

Cites

Investigating the effect of safranal on Bax and Bcl2 and oxidative stress levels in testis tissue of streptozotocin-induced diabetic rats

References

Cite

APA: Copy

Darbandi, Niloufar, MOGHADASI, SAMIRA, & MOMENI, HAMID REZA. (2017). COMPARING THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON SERUM OXIDATIVE STRESS FACTORS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(3), 206-221. SID. https://sid.ir/paper/36036/en

Vancouver: Copy

Darbandi Niloufar, MOGHADASI SAMIRA, MOMENI HAMID REZA. COMPARING THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON SERUM OXIDATIVE STRESS FACTORS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(3):206-221. Available from: https://sid.ir/paper/36036/en

IEEE: Copy

Niloufar Darbandi, SAMIRA MOGHADASI, and HAMID REZA MOMENI, “COMPARING THE ACUTE AND CHRONIC EFFECTS OF METFORMIN ON SERUM OXIDATIVE STRESS FACTORS IN STREPTOZOTOCIN-INDUCED ALZHEIMERIC MALE RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3, pp. 206–221, 2017, [Online]. Available: https://sid.ir/paper/36036/en

Related Journal Papers