THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON FATIGUE IN MULTIPLE SCLEROSIS

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ABOLHASANI MARYAM; RAZEGHI JAHROMI SOODEH; TOGHA MANSOUREH; SAHRAIAN MOHAMMAD ALI; SADR JAHANI SOLMAZ

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:4 Page(s): 30-36

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Title

THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON FATIGUE IN MULTIPLE SCLEROSIS

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Keywords

CREATINEQ3

FATIGUEQ2

MULTIPLE SCLEROSISQ2

NERVOUS SYSTEM DISEASESQ2

DIETARY SUPPLEMENTSQ3

Abstract

Introduction: FATIGUE is considered to be one of the main causes of impaired quality of life among patients with MULTIPLE SCLEROSIS (MS). CREATINE enhances ATP synthesis and possesses antioxidant properties. There has been interest in the use of CREATINE supplement for FATIGUE and muscle strength in neurological disorders. It has previously been reported that, using 20 gram/day CREATINE supplement for 5-7 days followed by 5 gram/day for another 7 days did not ameliorate FATIGUE in patients with MS. In this study, we aimed to determine whether longer application of CREATINE supplement would be effective in controlling FATIGUE in these patients.Materials and Methods: In a double-blind controlled trial, 20 patients with MS with FATIGUE and mild to moderate disability were randomly assigned to CREATINE (10 gram, two times a day for 14 days) and placebo (10 patients in each group). FATIGUE was assessed at baseline and after 14 days using FATIGUE severity scale (FSS).Results: No significant differences were observed between FSS score before and after the intervention. Furthermore, no significant difference was observed between the experimental groups in the mean difference of FSS.Conclusion: CREATINE supplementation had no significant effect on FATIGUE score even after longer administration.

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APA: Copy

ABOLHASANI, MARYAM, RAZEGHI JAHROMI, SOODEH, TOGHA, MANSOUREH, SAHRAIAN, MOHAMMAD ALI, & SADR JAHANI, SOLMAZ. (2014). THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON FATIGUE IN MULTIPLE SCLEROSIS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(4), 30-36. SID. https://sid.ir/paper/258132/en

Vancouver: Copy

ABOLHASANI MARYAM, RAZEGHI JAHROMI SOODEH, TOGHA MANSOUREH, SAHRAIAN MOHAMMAD ALI, SADR JAHANI SOLMAZ. THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON FATIGUE IN MULTIPLE SCLEROSIS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(4):30-36. Available from: https://sid.ir/paper/258132/en

IEEE: Copy

MARYAM ABOLHASANI, SOODEH RAZEGHI JAHROMI, MANSOUREH TOGHA, MOHAMMAD ALI SAHRAIAN, and SOLMAZ SADR JAHANI, “THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON FATIGUE IN MULTIPLE SCLEROSIS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 4, pp. 30–36, 2014, [Online]. Available: https://sid.ir/paper/258132/en

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