LONG-TERM POTENTIATION ENHANCED IN JUVENILE RAT BY REPETITIVE CORTICAL SPREADING DEPRESSION

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AHMADI MILAD; BANAZADEH DARDASHTI MEHRNAZ; MODARRES MOUSAVI SAYED MOSTAFA; KARIMZADEH FARIBA

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Title

LONG-TERM POTENTIATION ENHANCED IN JUVENILE RAT BY REPETITIVE CORTICAL SPREADING DEPRESSION

Author(s)

AHMADI MILAD | BANAZADEH DARDASHTI MEHRNAZ | MODARRES MOUSAVI SAYED MOSTAFA | KARIMZADEH FARIBA | Issue Writer Certificate

Keywords

LONG-TERM POTENTIATIONQ3

LEARNINGQ2

MEMORYQ2

NEURONAL PLASTICITYQ3

HIPPOCAMPUSQ3

Abstract

Introduction: Spreading depression (SD) is a bioelectrical event in the central nervous system and involves in the pathophysiology of some neurological disorders. In this present study, we indicate enhancement of LONG-TERM POTENTIATION of HIPPOCAMPUS tissue in juvenile rats faced to cortical spreading depression repetitively.Materials and Methods: Silver recording electrodes as well as a cannula were implanted over the brain of juvenile rats. Repetitive cortical SD events were induced by KCl 3 M weekly injection through the cannula. The brains were removed after 4 weeks. Transverse sections were prepared and incubated in artificial cerebrospinal fluid. Single electrical stimulations were applied through a bipolar electrode placed on to the hippocampal Schaffer collaterals. The field excitatory postsynaptic potentials (fEPSP) were elicited by adjusting the intensity of stimulation to 50% of that at which population spikes began to appear.Results: Repetitive SD enhanced the LONG-TERM POTENTIATION in CA1 hippocampal area. The data indicate that repetitive cortical SD in juvenile rats significantly increases the amplitude of the fEPSP form the baseline.Conclusion: This may clarify the pathophysiology of MEMORY deficit were seen in some neurological disorders in children.

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APA: Copy

AHMADI, MILAD, BANAZADEH DARDASHTI, MEHRNAZ, MODARRES MOUSAVI, SAYED MOSTAFA, & KARIMZADEH, FARIBA. (2013). LONG-TERM POTENTIATION ENHANCED IN JUVENILE RAT BY REPETITIVE CORTICAL SPREADING DEPRESSION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 1(3), 33-37. SID. https://sid.ir/paper/258141/en

Vancouver: Copy

AHMADI MILAD, BANAZADEH DARDASHTI MEHRNAZ, MODARRES MOUSAVI SAYED MOSTAFA, KARIMZADEH FARIBA. LONG-TERM POTENTIATION ENHANCED IN JUVENILE RAT BY REPETITIVE CORTICAL SPREADING DEPRESSION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2013;1(3):33-37. Available from: https://sid.ir/paper/258141/en

IEEE: Copy

MILAD AHMADI, MEHRNAZ BANAZADEH DARDASHTI, SAYED MOSTAFA MODARRES MOUSAVI, and FARIBA KARIMZADEH, “LONG-TERM POTENTIATION ENHANCED IN JUVENILE RAT BY REPETITIVE CORTICAL SPREADING DEPRESSION,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 1, no. 3, pp. 33–37, 2013, [Online]. Available: https://sid.ir/paper/258141/en

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