THE ROLE OF GLIAL CELLS IN BASELINE SYNAPTIC RESPONSE AND SHORT TERM SYNAPTIC PLASTICITY OF CA1 AREA OF THE HIPPOCAMPUS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Elahi Mahani Azadeh; HOSSEINMARDI NARGES; JANAHMADI MAHYAR; Seyedaghamiri Fatemehsadat; Hooshmandi Mehdi

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2016 | Volume:26 | Issue:135 Page(s): 51-61

Download Full-Text

Persian Verion

View:

885

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF GLIAL CELLS IN BASELINE SYNAPTIC RESPONSE AND SHORT TERM SYNAPTIC PLASTICITY OF CA1 AREA OF THE HIPPOCAMPUS

Author(s)

Keywords

HIPPOCAMPUSQ2

GGLIAL CELLSQ1

SYNAPTIC PLASTICITYQ1

Abstract

Background and purpose: Glial cells seem to play role in SYNAPTIC PLASTICITY because they have the ability to release trophic factors and gliotransmitters and respond to neurotransmitters. They also play important role in synaptic space homeostasis. In this study, the role of hippocampal glial cells in baseline synaptic response and short term SYNAPTIC PLASTICITY were investigated.Materials and methods: In this experimental study, flourocitrate, glia inhibitor (1nmol/0.5μl), was microinjected intrahippcampally for inhibition of hippocampal glial cells. Baseline synaptic response and short term SYNAPTIC PLASTICITY were evaluated by field potential recording. fEPSP was recorded from CA1 following Schaffer collaterals stimulation. After Input/Output curve construction, short term SYNAPTIC PLASTICITY was induced by paired pulse stimulations.Results: Inhibition of glial cells by flourocitrate microinjection in CA1 did not have any effect on baseline synaptic response (P>0.05). Flourocitrate increased paired pulse index (PPI, control: 62.80%±5.48; flourocitrate treated: 87.19%±12.11) at 20 ms inter pulse interval (P<0.05). But it did not affect PPI at 80 and 200 ms IPI (P>0.05).Conclusion: The results suggest that hippocampal glial cells functions did not influence the baseline synaptic response but affected short term SYNAPTIC PLASTICITY in CA1 area of the HIPPOCAMPUS.

Cites

No record.

References

No record.

Cite

APA: Copy

Elahi Mahani, Azadeh, HOSSEINMARDI, NARGES, JANAHMADI, MAHYAR, Seyedaghamiri, Fatemehsadat, & Hooshmandi, Mehdi. (2016). THE ROLE OF GLIAL CELLS IN BASELINE SYNAPTIC RESPONSE AND SHORT TERM SYNAPTIC PLASTICITY OF CA1 AREA OF THE HIPPOCAMPUS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(135), 51-61. SID. https://sid.ir/paper/45696/en

Vancouver: Copy

Elahi Mahani Azadeh, HOSSEINMARDI NARGES, JANAHMADI MAHYAR, Seyedaghamiri Fatemehsadat, Hooshmandi Mehdi. THE ROLE OF GLIAL CELLS IN BASELINE SYNAPTIC RESPONSE AND SHORT TERM SYNAPTIC PLASTICITY OF CA1 AREA OF THE HIPPOCAMPUS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(135):51-61. Available from: https://sid.ir/paper/45696/en

IEEE: Copy

Azadeh Elahi Mahani, NARGES HOSSEINMARDI, MAHYAR JANAHMADI, Fatemehsadat Seyedaghamiri, and Mehdi Hooshmandi, “THE ROLE OF GLIAL CELLS IN BASELINE SYNAPTIC RESPONSE AND SHORT TERM SYNAPTIC PLASTICITY OF CA1 AREA OF THE HIPPOCAMPUS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 135, pp. 51–61, 2016, [Online]. Available: https://sid.ir/paper/45696/en

Related Journal Papers