The Role of Serotonin and Dopamine Neurotransmitters in Obsessive-Compulsive Disorder

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Nabizadeh Mohammad

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Journal Paper

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Journal: Neuroscience Journal of Shefaye Khatam Year:2019 | Volume:7 | Issue:2 Page(s): 99-106

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Information Journal Paper

Title

The Role of Serotonin and Dopamine Neurotransmitters in Obsessive-Compulsive Disorder

Author(s)

Nabizadeh Mohammad | Issue Writer Certificate

Keywords

Obsessive-Compulsive DisorderQ1

SerotoninQ2

DopamineQ2

ModelsQ2

AnimalQ2

Abstract

Introduction: Therapeutic advances, brain imaging s tudies, and the results of drug-related research, have led to revising the etiology theories of Obsessive-Compulsive Disorder (OCD) and es tablishing new research paradigms. OCD is considered as a psychiatric neuropathy with an essential biological nerve abnormality. In this context, the important determinant factor of the human quality of thinking is the processing of information in different neuronal networks. The microenvironment of the brain is important for the efficiency and accuracy of thought. In the present s tudy, the neurochemical properties and the role of various neurotransmitters in OCD are discussed. Conclusion: Numerous s tudies have shown that the serotonergic 5-HT2C receptor plays an important role in the pathophysiology of OCD. Furthermore, OCD is associated with changes in the s triatal serotonergic sys tem. The density of the serotonergic neurotransmitters markedly increases in the s triatum. In addition to Serotonin, Dopaminergic D3, D2, D1 receptors play a crucial role in the development of OCD. A significant enhancement of Dopamine function is observed in the nucleus accumbens and right prefrontal cortex.

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APA: Copy

Nabizadeh, Mohammad. (2019). The Role of Serotonin and Dopamine Neurotransmitters in Obsessive-Compulsive Disorder. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(2 ), 99-106. SID. https://sid.ir/paper/258189/en

Vancouver: Copy

Nabizadeh Mohammad. The Role of Serotonin and Dopamine Neurotransmitters in Obsessive-Compulsive Disorder. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(2 ):99-106. Available from: https://sid.ir/paper/258189/en

IEEE: Copy

Mohammad Nabizadeh, “The Role of Serotonin and Dopamine Neurotransmitters in Obsessive-Compulsive Disorder,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 2 , pp. 99–106, 2019, [Online]. Available: https://sid.ir/paper/258189/en

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