THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE

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ZAMANI ESMATI MAHYA; MALEKZADEH HANIEH; JENAB ESFAHANI HANIEH; ESHAGHABADI AREZOU; GHASEMI SEDIGHEH; JAFARIANI MARYAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:1 Page(s): 42-48

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Title

THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE

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Keywords

CARBAMAZEPINEQ3

EPILEPSYQ2

SEIZURESQ2

PENTYLENETETRAZOLEQ3

HIPPOCAMPUSQ2

Abstract

Introduction: EPILEPSY is the most common disorder of the central nerves system. Studies showed that CARBAMAZEPINE has anti-epileptic effects. However, there is no evidence whether CARBAMAZEPINE protect seizure-induced neuronal injury. In this study, the effects of CARBAMAZEPINE were evaluated on cell injury observed in PENTYLENETETRAZOLE (PTZ) model of seizure in the rat brain.Materials and Methods: The convulsive behaviour and histological evaluation were performed in age- and weight-matched rats, which were divided into five groups: 1.control group: without any intervention, 2. PTZ group: after PTZ injection (40 mg/ kg), 3. Sham group: vehicles were injected 30 min before PTZ injection (40 mg/ kg), 4. Treatment group 1: CARBAMAZEPINE (10 mg/kg) was injected 30 min before PTZ injection, 5. Treatment group 2: CARBAMAZEPINE (40 mg/kg) was injected 30 min before PTZ injection.Results: CARBAMAZEPINE significantly decreased production of the dark neurons in the hippocampal CA1 and CA3 areas and the temporal cortex after PTZ-induced seizure compared to PTZ and sham groups. Density of dark neurons in treatment groups was significantly higher than control group.Conclusion: The results showed that CARBAMAZEPINE acts as a neuroprotective substance after seizure attacks.

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