NEUROPROTECTIVE EFFECTS OF CONCOMITANT USE OF ERYTHROPOIETIN AND PROGESTERONE IN TRAUMATIC BRAIN INJURY

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NOURZAD ZAHRA; KHAZALI HOMAYON; GHADIRI TAHEREH; MODARRES MOUSAVI SAYED MOSTAFA; KARIMZADEH FARIBA; ESHAGHABADI AREZOU; HOSSEINI RAVANDI HASSAN; AGHABARARI AFSANEH; GORJI ALI

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:2 Page(s): 1-12

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Title

NEUROPROTECTIVE EFFECTS OF CONCOMITANT USE OF ERYTHROPOIETIN AND PROGESTERONE IN TRAUMATIC BRAIN INJURY

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Keywords

BRAIN INJURIESQ3

PROGESTERONEQ3

ERYTHROPOIETINQ3

NEUROPROTECTIVE AGENTSQ3

Abstract

Introduction: Traumatic BRAIN INJURIES may cause some neurological deficits, such as altered level of consciousness or coma, sensory-motor dysfunction, and seizure attacks. The neuroprotective effect of PROGESTERONE and ERYTHROPOIETIN has been shown in different types of BRAIN INJURIES and cerebral ischemia. This study aims to evaluate the probable additional neuroprotective effects of PROGESTERONE and ERYTHROPOIETIN after brain injury.Materials and Methods: The effects of PROGESTERONE, ERYTHROPOIETIN or the combination of these substances were investigated in 54 male Wistar rats suffering from traumatic brain injury. The effects of drugs were investigated using Modified Neurological Severity Scores as well as counting the number of dark neurons (injured cells) in the hippocampal CA1 and CA3 areas.Results: Our data revealed that the scale of neurological deficits increased by co-application of PROGESTERONE and ERYTHROPOIETIN in brain-injured rats. Assessment of dark neurons did not show a significant decrease in the number of dark neurons after combined treatment compared to control groups.Conclusion: Our study showed that the combination therapy did not exhibit any synergistic effect and may worsen the outcome of traumatic brain injury.

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APA: Copy

NOURZAD, ZAHRA, KHAZALI, HOMAYON, GHADIRI, TAHEREH, MODARRES MOUSAVI, SAYED MOSTAFA, KARIMZADEH, FARIBA, ESHAGHABADI, AREZOU, HOSSEINI RAVANDI, HASSAN, AGHABARARI, AFSANEH, & GORJI, ALI. (2014). NEUROPROTECTIVE EFFECTS OF CONCOMITANT USE OF ERYTHROPOIETIN AND PROGESTERONE IN TRAUMATIC BRAIN INJURY. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(2), 1-12. SID. https://sid.ir/paper/258218/en

Vancouver: Copy

NOURZAD ZAHRA, KHAZALI HOMAYON, GHADIRI TAHEREH, MODARRES MOUSAVI SAYED MOSTAFA, KARIMZADEH FARIBA, ESHAGHABADI AREZOU, HOSSEINI RAVANDI HASSAN, AGHABARARI AFSANEH, GORJI ALI. NEUROPROTECTIVE EFFECTS OF CONCOMITANT USE OF ERYTHROPOIETIN AND PROGESTERONE IN TRAUMATIC BRAIN INJURY. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(2):1-12. Available from: https://sid.ir/paper/258218/en

IEEE: Copy

ZAHRA NOURZAD, HOMAYON KHAZALI, TAHEREH GHADIRI, SAYED MOSTAFA MODARRES MOUSAVI, FARIBA KARIMZADEH, AREZOU ESHAGHABADI, HASSAN HOSSEINI RAVANDI, AFSANEH AGHABARARI, and ALI GORJI, “NEUROPROTECTIVE EFFECTS OF CONCOMITANT USE OF ERYTHROPOIETIN AND PROGESTERONE IN TRAUMATIC BRAIN INJURY,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 2, pp. 1–12, 2014, [Online]. Available: https://sid.ir/paper/258218/en

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