THE SURVEY OF SAFFRON EXTRACT EFFECTS ON EXPRESSIONAL PATTERN OF SOME SELF-RENEWAL GENES IN AGS (GASTRIC ADENOCARCINOMA) TUMOR CELL LINE

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AKBARPOOR V.; BAGREZAEI F.; MAHMOODI M.; HAJIZADEH M.R.; SHEIKH FATHOLLAHI M.; MIRZAEI M.R.

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Journal: COMMUNITY HEALTH JOURNAL Year:2017 | Volume:10 | Issue:4 Page(s): 66-75

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Title

THE SURVEY OF SAFFRON EXTRACT EFFECTS ON EXPRESSIONAL PATTERN OF SOME SELF-RENEWAL GENES IN AGS (GASTRIC ADENOCARCINOMA) TUMOR CELL LINE

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Keywords

SAFFRONQ3

ADENOCARCINOMA CANCER CELL LINE (AGS)Q1

GENE EXPRESSIONQ1

Abstract

Introduction: The aim of the present study was to investigate the effect of different concentrations of SAFFRON (Crocus sativus) on the expression of OCT4, KLF, SOX2, NANOG and Nucleostemin genes in AGS (gastric cancer) cell line.Materials and Methods: Gastric adenocarcinoma cell line (AGS) was prepared from the cell bank of Iran Pasteur Institute and were cultured in RPMI 1640 medium. The cells were then cultured in both test and control groups under similar conditions. At confluency of 60-70%, the test group was treated with SAFFRON essence at concentrations of 20, 40 and 100 mg/ml for 24, 48 and 72 hours. Total RNA was extracted prior to cDNA preparation. The expression of target genes in both test and control groups were determined.Results: The results showed that the SAFFRON extract decreased expression of OCT4, KLF, SOX2, NANOG and Nucleostemin genes.Conclusion: The results suggested that SAFFRON can be considered as an anti-cancer agent due to its role in inhibition of cell division. This study could be the basis for further studies on the anti-cancer property of herbal products.

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APA: Copy

AKBARPOOR, V., BAGREZAEI, F., MAHMOODI, M., HAJIZADEH, M.R., SHEIKH FATHOLLAHI, M., & MIRZAEI, M.R.. (2017). THE SURVEY OF SAFFRON EXTRACT EFFECTS ON EXPRESSIONAL PATTERN OF SOME SELF-RENEWAL GENES IN AGS (GASTRIC ADENOCARCINOMA) TUMOR CELL LINE. COMMUNITY HEALTH JOURNAL, 10(4 ), 66-75. SID. https://sid.ir/paper/262879/en

Vancouver: Copy

AKBARPOOR V., BAGREZAEI F., MAHMOODI M., HAJIZADEH M.R., SHEIKH FATHOLLAHI M., MIRZAEI M.R.. THE SURVEY OF SAFFRON EXTRACT EFFECTS ON EXPRESSIONAL PATTERN OF SOME SELF-RENEWAL GENES IN AGS (GASTRIC ADENOCARCINOMA) TUMOR CELL LINE. COMMUNITY HEALTH JOURNAL[Internet]. 2017;10(4 ):66-75. Available from: https://sid.ir/paper/262879/en

IEEE: Copy

V. AKBARPOOR, F. BAGREZAEI, M. MAHMOODI, M.R. HAJIZADEH, M. SHEIKH FATHOLLAHI, and M.R. MIRZAEI, “THE SURVEY OF SAFFRON EXTRACT EFFECTS ON EXPRESSIONAL PATTERN OF SOME SELF-RENEWAL GENES IN AGS (GASTRIC ADENOCARCINOMA) TUMOR CELL LINE,” COMMUNITY HEALTH JOURNAL, vol. 10, no. 4 , pp. 66–75, 2017, [Online]. Available: https://sid.ir/paper/262879/en

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