THE FREQUENCY OF ABNORMAL E-CADHERIN EXPRESSION AND ITS RELATIONSHIP WITH BIOLOGICAL BEHAVIOR OF GASTRIC ADENOCARCINOMA

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SIRI G.; FARAHVASH M.; EBRAHIMI DARYANI N.; JAHANZAD I.; NASIRITOOSI M.; KALANI M.; FORUTAN H.; ALETAHA N.

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Journal: GOVARESH JOURNAL Year:2010 | Volume:15 | Issue:3 (SN 72) Page(s): 188-194

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Title

THE FREQUENCY OF ABNORMAL E-CADHERIN EXPRESSION AND ITS RELATIONSHIP WITH BIOLOGICAL BEHAVIOR OF GASTRIC ADENOCARCINOMA

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Keywords

E-CADHERINQ3

IMMUNOHISTOCHEMISTRYQ3

GASTRIC ADENOCARCINOMAQ3

BIOLOGICAL BEHAVIORQ3

Abstract

Background: E-CADHERIN is a calcium-dependent molecule that contributes to intercellular adhesion. Its proper functioning is important in the maintenance of epithelial structure and integrity. E-CADHERIN serves as a very important tumor suppressor. In this study, we aim to determine the frequency of E-CADHERIN expression aberrancy and its relationship to the BIOLOGICAL BEHAVIOR of GASTRIC ADENOCARCINOMA.Methods: A total of 52 patients with gastric cancer who underwent gastrectomies in Imam Khomeini Hospital were investigated in a cross-sectional study. Their tissues were stained by IMMUNOHISTOCHEMISTRY methods to investigate the expression of E-CADHERIN. Patients’ information including age, gender, Helicobacter pylori infection, lesion location, adenocarcinoma subtype, metastasis, differentiation and regional lymph node involvement, depth of invasion and staging were collected and compared.Results: Age, gender, Helicobacter pylori infection, lesion location, regional lymph node involvement, metastasis, depth of invasion, differentiation and staging did not have a statistically significant relationship with abnormal E-CADHERIN expression. Abnormal E-CADHERIN expression was significantly higher in the diffuse sub-type as compared with the intestinal type (90.9% vs.48.8%, p=0.016).Conclusions: The present study assessed the frequency and relationship between abnormal E-CADHERIN expression and certain biological variables of tumor behavior in Iranian patients with GASTRIC ADENOCARCINOMA. A significant correlation existed only between diffuse sub-typing and reduced E-CADHERIN expression.

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APA: Copy

SIRI, G., FARAHVASH, M., JAHANZAD, I., NASIRITOOSI, M., KALANI, M., EBRAHIMI DARYANI, N., FORUTAN, H., & ALETAHA, N.. (2010). THE FREQUENCY OF ABNORMAL E-CADHERIN EXPRESSION AND ITS RELATIONSHIP WITH BIOLOGICAL BEHAVIOR OF GASTRIC ADENOCARCINOMA. GOVARESH JOURNAL, 15(3 (SN 72)), 188-194. SID. https://sid.ir/paper/86261/en

Vancouver: Copy

SIRI G., FARAHVASH M., JAHANZAD I., NASIRITOOSI M., KALANI M., EBRAHIMI DARYANI N., FORUTAN H., ALETAHA N.. THE FREQUENCY OF ABNORMAL E-CADHERIN EXPRESSION AND ITS RELATIONSHIP WITH BIOLOGICAL BEHAVIOR OF GASTRIC ADENOCARCINOMA. GOVARESH JOURNAL[Internet]. 2010;15(3 (SN 72)):188-194. Available from: https://sid.ir/paper/86261/en

IEEE: Copy

G. SIRI, M. FARAHVASH, I. JAHANZAD, M. NASIRITOOSI, M. KALANI, N. EBRAHIMI DARYANI, H. FORUTAN, and N. ALETAHA, “THE FREQUENCY OF ABNORMAL E-CADHERIN EXPRESSION AND ITS RELATIONSHIP WITH BIOLOGICAL BEHAVIOR OF GASTRIC ADENOCARCINOMA,” GOVARESH JOURNAL, vol. 15, no. 3 (SN 72), pp. 188–194, 2010, [Online]. Available: https://sid.ir/paper/86261/en

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