THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT

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SHAFIEE K.; BAREKATEYN M.; BASHARDOUST N.A.; MAHMOUDI J.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:8 | Issue:4 Page(s): 25-29

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Title

THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT

Author(s)

SHAFIEE K. | BAREKATEYN M. | BASHARDOUST N.A. | MAHMOUDI J. | Issue Writer Certificate

Keywords

ACUTE MANIC EPISODEQ4

DSMQ4

IVQ4

SODIUM VALPROATEQ4

YOUNG MANIA RATING SCALEQ4

Abstract

Introduction: Acheiving accelerated clinical response is desirable in patients with ACUTE MANIC EPISODE. We conducted a prospective study to compare the rate of clinical response of oral loading SODIUM VALPROATE versus standard dose titration.Methods: Fourty - two patients who met DSM - IV critevia for current manic episode and who had a "Young mania rating scale "score between 20 and 50 were randomly assigned on a double blind basis to recieve valproate oral "loading"(N=21) at a dose of 20 mg/kg in divided doses for 7 days and valproate "non -loading" at a starting dose of 10 mg/kg followed by standard titration which at day 6 , they recieved 20 mg/kg valproate. Patients were scored at day 0, 3, 5 and 7 by a blindraterusing YMRS.Results: There was no significat differences between the groups in advers events and useing of adjunctive tranquilizer .The efficacy of valproate in both two groups was similar but " the rate of improvement on YMRS" over the first 3 days was significantly greater in loading group. Conclusion: Valproate oral loading with SODIUM VALPROATE can induced a more rapid clinical response in acutely manic patient.

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APA: Copy

SHAFIEE, K., BAREKATEYN, M., BASHARDOUST, N.A., & MAHMOUDI, J.. (2003). THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 8(4), 25-29. SID. https://sid.ir/paper/26641/en

Vancouver: Copy

SHAFIEE K., BAREKATEYN M., BASHARDOUST N.A., MAHMOUDI J.. THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;8(4):25-29. Available from: https://sid.ir/paper/26641/en

IEEE: Copy

K. SHAFIEE, M. BAREKATEYN, N.A. BASHARDOUST, and J. MAHMOUDI, “THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 8, no. 4, pp. 25–29, 2003, [Online]. Available: https://sid.ir/paper/26641/en

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